Survey of Ophthalmology
Volume 45, Issue 1 , Pages 49-68 , 15 July 2000

The Role of the Immune System in Conjunctival Wound Healing After Glaucoma Surgery

  • L Chang, FRCOphth

      Affiliations

    • Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, London, United Kingdom
    • Department of Immunology, Royal Free & University College School of Medicine, London, United Kingdom
    • Corresponding Author InformationReprint address: L Chang, FRCOphth, Wound Healing Research Unit, Department of Pathology, Institute of Ophthalmology, Bath Street, London, EC1V 9EL, United Kingdom
    • ,
  • J.G Crowston, FRCOphth

      Affiliations

    • Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, London, United Kingdom
    • ,
  • M.Francesca Cordeiro, PhD, MRCP, FRCOphth

      Affiliations

    • Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, London, United Kingdom
    • ,
  • A.N Akbar, MRCPath, PhD, BSc

      Affiliations

    • Department of Immunology, Royal Free & University College School of Medicine, London, United Kingdom
    • ,
  • P.T Khaw, PhD, FRCP, FRCS, FRCOphth

      Affiliations

    • Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, London, United Kingdom
    • Department of Pathology and Glaucoma, Moorfields Eye Hospital NHS Trust and Institute of Ophthalmology, London, United Kingdom

References 

  1. Abdel-Khalek LM, Williamson J, Lee WR. Morphological changes in the human conjunctival epithelium. I. In the normal elderly population. Br J Ophthalmol. 1978;62:792–799
  2. Addicks EM, Quigley HA, Green WR, Robin AL. Histologic characteristics of filtering blebs in glaucomatous eyes. Arch Ophthalmol. 1983;101:795–798
  3. Adelmann-Grill BC, Wach F, Cully Z, et al.  Chemotactic migration of normal dermal fibroblasts towards epidermal growth factor and its modulation by platelet-derived growth factor and transforming growth factor-beta. Eur J Cell Biol. 1990;51:322–326
  4. Adolph VR, DiSanto SK, Bleacher JC, et al.  The potential role of the lymphocyte in fetal wound healing. J Pediatr Surg. 1993;28:1316–1320
  5. Adzick NS, Harrison MR, Glick PL, et al.  Comparison of fetal, newborn, and adult wound healing by histologic, enzyme-histochemical, and hydroxyproline determinations. J Pediatr Surg. 1985;20:315–319
  6. Ahuja SS, Shrivastav S, Danielpour D, et al.  Regulation of transforming growth factor-beta 1 and its receptor by cyclosporine in human T lymphocytes. Transplantation. 1995;60:718–723
  7. Akbar AN, Borthwick N, Salmon M, et al.  The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J Exp Med. 1993;178:427–438
  8. Akbar AN, Salmon M. Cellular environments and apoptosis (tissue microenvironments control activated T-cell death). Immunology Today. 1997;18:72–76
  9. Allansmith MR, Greiner JV, Baird RS. Number of inflammatory cells in the normal conjunctiva. Am J Ophthalmol. 1978;86:250–259
  10. Andersen SR, Jensen OA, Kristensen EB, Norn MS. Benign mucous membrane pemphigoid. 3. Biopsy. Acta Ophthalmol. 1974;52:455–463
  11. Anonymous . Five-year follow-up of the Fluorouracil Filtering Surgery Study. The Fluorouracil Filtering Surgery Study Group. Am J Ophthalmol. 1996;121:349–366
  12. Araujo SV, Spaeth GL, Roth SM, Starita RJ. A ten-year follow-up on a prospective, randomized trial of postoperative corticosteroids after trabeculectomy. Ophthalmology. 1995;102:1753–1759
  13. Ashcroft GS, Herrick SE, Tarnuzzer RW, et al.  Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA. J Pathol. 1997;183:169–176
  14. Ashcroft GS, Horan MA, Ferguson MW. Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model. J Invest Dermatol. 1997;108:430–437
  15. Ashcroft GS, Horan MA, Ferguson MW. Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab Invest. 1998;78:47–58
  16. Assoian RK, Fleurdelys BE, Stevenson HC, et al.  Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci USA. 1987;84:6020–6024
  17. Assoian RK, Komoriya A, Meyers CA, et al.  Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 1983;258:7155–7160
  18. Bahn RS, Heufelder A. Pathogenesis of Graves' ophthalmopathy. N Engl J Med. 1993;329:1468–1475
  19. Ball SF, Vinh T, Gebhardt BM. Biphasic effect of corticosteroids on protein and DNA synthesis by human subconjunctival fibroblasts in culture. Invest Ophthalmol Vis Sci (Suppl). 1987;28:S378;[abstract]
  20. Barbul A, Breslin RJ, Woodyard JP, et al.  The effect of in vivo T helper and T suppressor lymphocyte depletion on wound healing. Ann Surg. 1989;209:479–483
  21. Barbul A, Regan MC. Immune involvement in wound healing. Otolaryngol Clin N Am. 1995;28:955–968
  22. Barbul A, Rettura G, Levenson SM, Seifter E. Arginine (a thymotropic and wound-healing promoting agent). Surg Forum. 1977;28:101–103
  23. Barbul A, Shawe T, Frankel HL, et al.  Inhibition of wound repair by thymic hormones. Surgery. 1989;106:373–376
  24. Barbul A, Shawe T, Rotter SM, et al.  Wound healing in nude mice (a study on the regulatory role of lymphocytes in fibroplasia). Surgery. 1989;105:764–769
  25. Barbul A, Sisto D, Rettura G, et al.  Thymic inhibition of wound healing (abrogation by adult thymectomy). J Surg Res. 1982;32:338–342
  26. Baudouin C, Garcher C, Haouat N, et al.  Expression of inflammatory membrane markers by conjunctival cells in chronically treated patients with glaucoma. Ophthalmology. 1994;101:454–460
  27. Baudouin C, Pisella PJ, Fillacier K, et al.  Ocular surface inflammatory changes induced by topical antiglaucoma drugs (human and animal studies). Ophthalmology. 1999;106:556–563
  28. Baun O, Heegaard S, Kessing SV, Prause JU. The morphology of conjunctiva after long-term topical anti-glaucoma treatment. A quantitative analysis. Acta Ophthalmol Scand. 1995;73:242–245
  29. Beck LS, DeGuzman L, Lee WP, et al.  One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing. J Clin Invest. 1993;92:2841–2849
  30. Becker S, Warren MK, Haskill S. Colony-stimulating factor-induced monocyte survival and differentiation into macrophages in serum-free cultures. J Immunol. 1987;139:3703–3709
  31. Becquet F, Goldschild M, Moldovan MS, et al.  Histopathological effects of topical ophthalmic preservatives on rat corneoconjunctival surface. Curr Eye Res. 1998;17:419–425
  32. Beezhold DH, Personius C. Fibronectin fragments stimulate tumor necrosis factor secretion by human monocytes. J Leukocyte Biol. 1992;51:59–64
  33. Bennett NT, Schultz GS. Growth factors and wound healing (biochemical properties of growth factors and their receptors). Am J Surg. 1993;165:728–737
  34. Bergstrom TJ, Wilkinson WS, Skuta GL, et al.  The effects of subconjunctival mitomycin-C on glaucoma filtration surgery in rabbits. Arch Ophthalmol. 1991;109:1725–1730
  35. Berman B, Duncan MR. Short-term keloid treatment in vivo with human interferon alfa-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro. J Am Acad Dermatol. 1989;21:694–702
  36. Bernauer W, Broadway DC, Wright P. Chronic progressive conjunctival cicatrisation. Eye. 1993;7:371–378
  37. Bernauer W, Itin PH, Kirtschig G. Cicatricial pemphigoid. Devel Ophthalmol. 1997;28:46–63
  38. Bernauer W, Wright P, Dart JK, et al.  Cytokines in the conjunctiva of acute and chronic mucous membrane pemphigoid (an immunohistochemical analysis). Graefes Arch Clin Exp Ophthalmol. 1993;231:563–570
  39. Bernauer W, Wright P, Dart JK, et al.  The conjunctiva in acute and chronic mucous membrane pemphigoid. An immunohistochemical analysis. The value of biopsies in the evaluation of chronic progressive conjunctival cicatrisation. Ophthalmology. 1993;100:339–346
  40. Bevilacqua MP, Pober JS, Wheeler ME, et al.  Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest. 1985;76:2003–2011
  41. Blumenkranz MS, Claflin A, Hajek AS. Selection of therapeutic agents for intraocular proliferative disease. Cell culture evaluation. Arch Ophthalmol. 1984;102:598–604
  42. Brandt JD, Wittpenn JR, Katz LJ, et al.  Conjunctival impression cytology in patients with glaucoma using long-term topical medication. Am J Ophthalmol. 1991;112:297–301
  43. Breslin RJ, Wasserkrug HL, Efron G, Barbul A. Suppressor cell generation during normal wound healing. J Surg Res. 1988;44:321–325
  44. Brignole F, De Saint-Jean M, Goldschild M, et al.  Expression of Fas-Fas ligand antigens and apoptotic marker APO2.7 by the human conjunctival epithelium. Positive correlation with class II HLA DR expression in inflammatory ocular surface disorders. Exp Eye Res. 1998;67:687–697
  45. Broadway D. Drug-induced conjunctival cicatrisation. Develop Ophthalmol. 1997;28:86–101
  46. Broadway D, Grierson I, Hitchings R. Racial differences in the results of glaucoma filtration surgery (are racial differences in the conjunctival cell profile important?). Br J Ophthalmol. 1994;78:466–475
  47. Broadway DC, Bates AK, Lightman SL, et al.  The importance of cellular changes in the conjunctiva of patients with uveitic glaucoma undergoing trabeculectomy. Eye. 1993;7:495–501
  48. Broadway DC, Grierson I, O'Brien C, Hitchings RA. Adverse effects of topical antiglaucoma medication. I. The conjunctival cell profile. Arch Ophthalmol. 1994;112:1437–1445
  49. Broadway DC, Grierson I, O'Brien C, Hitchings RA. Adverse effects of topical antiglaucoma medication. II. The outcome of filtration surgery. Arch Ophthalmol. 1994;112:1446–1454
  50. Brunner T, Mogil RJ, LaFace D, et al.  Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature. 1995;373:441–444
  51. Bucala R, Spiegel LA, Chesney J, et al.  Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Molec Med. 1994;1:71–81
  52. Buchmuller-Rouiller Y, Mauel J. Macrophage activation for intracellular killing as induced by calcium ionophore. Correlation with biologic and biochemical events. J Immunol. 1991;146:217–223
  53. Burger D, Rezzonico R, Li JM, et al.  Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes (involvement of membrane-associated cytokines). Arthritis Rheum. 1998;41:1748–1759
  54. Cerwenka A, Kovar H, Majdic O, Holter W. Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1. J Immunol. 1996;156:459–464
  55. Chai JG, Bartok I, Chandler P, et al.  Anergic T cells act as suppressor cells in vitro and in vivo. Eur J Immunol. 1999;29:686–692
  56. Chan CC, Nussenblatt RB, Ni M, et al.  Immunohistochemical markers in the normal human epibulbar conjunctiva from fetus to adult. Arch Ophthalmol. 1988;106:215–217
  57. Charteris DG, Hiscott P, Grierson I, Lightman SL. Lymphocytes in epiretinal membranes. Ophthalmology. 1992;99:1364–1367
  58. Charteris DG, Hiscott P, Grierson I, Lightman SL. Inflammatory cells in proliferative vitreoretinopathy subretinal membranes. Ophthalmology. 1993;100:43–46
  59. Chen CW, Huang HT, Bair JS, Lee CC. Trabeculectomy with simultaneous topical application of mitomycin-C in refractory glaucoma. J Ocul Pharmacol. 1990;6:175–182
  60. Chesney J, Metz C, Stavitsky AB, et al.  Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. J Immunol. 1998;160:419–425
  61. Cheung JC, Wright MM, Murali S, Pederson JE. Intermediate-term outcome of variable dose mitomycin C filtering surgery. Ophthalmology. 1997;104:143–149
  62. Chizzolini C, Rezzonico R, Ribbens C, et al.  Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells (different sensitivity to inhibition between systemic sclerosis and control fibroblasts). Arthritis Rheum. 1998;41:2039–2047
  63. Connor TBJ, Roberts AB, Sporn MB, et al.  Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. J Clin Invest. 1989;83:1661–1666
  64. Cordeiro MF, Gay JA, Khaw PT. Human anti-transforming growth factor-β2 antibody (a new glaucoma anti-scarring agent). Invest Ophthalmol Vis Sci. 1999;40:2225–2234
  65. Cordeiro MF, Reichel MB, Gay JA, et al.  Transforming growth factor-β1, -β2, and -β3 in vivo (effects on normal and mitomycin C-modulated conjunctival scarring). Invest Ophthalmol Vis Sci. 1999;40:1975–1982
  66. Cox DA. Transforming growth factor-beta 3. Cell Biol Int. 1995;19:357–371
  67. Cromack DT, Porras-Reyes B, Purdy JA, et al.  Acceleration of tissue repair by transforming growth factor beta 1 (identification of in vivo mechanism of action with radiotherapy-induced specific healing deficits). Surgery. 1993;113:36–42
  68. Crowston JG, Akbar AN, Constable PH, et al.  Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts. Invest Ophthalmol Vis Sci. 1998;39:449–454
  69. Cunliffe I, McIntyre C, Rees R, Rennie I. The effect of topical beta-blocker medications on the proliferation and viability of human Tenon's capsule fibroblasts in tissue culture. German J Ophthalmol. 1995;4:167–174
  70. Cunliffe IA, Richardson PS, Rees RC, Rennie IG. Effect of TNF, IL-1, and IL-6 on the proliferation of human Tenon's capsule fibroblasts in tissue culture. Br J Ophthalmol. 1995;79:590–595
  71. Cupps TR, Fauci AS. Corticosteroid-mediated immunoregulation in man. Immunol Rev. 1982;65:133–155
  72. D'Orazio TJ, Niederkorn JY. A novel role for TGF-β and IL-10 in the induction of immune privilege. J Immunol. 1998;160:2089–2098
  73. Dabrowski R, Drobnik J. The effect of disodium cromoglycate on the skin wound healing and collagen content in the wounds of rats. Acta Physiologica Polonica. 1990;41:195–198
  74. Damji KF, Rootman J, Palcic B, Thurston G. Pharmacological modulation of human subconjunctival fibroblast behaviour in vitro. Ophthalmic Surg. 1990;21:31–43
  75. Danon D, Kowatch MA, Roth GS. Promotion of wound repair in old mice by local injection of macrophages. Proc Natl Acad Sci USA. 1989;86:2018–2020
  76. De-Quan L, Lee S-B, Tseng SCG. Differential expression and regulation of TGF-β1, TGF-β2, TGF-β3, TGF-βRI, TGF-βRII, and TGF-βRIII in cultured human corneal, limbal and conjunctival fibroblasts. Curr Eye Res. 1999;19:154–161
  77. De Saint JM, Brignole F, Bringuier AF, et al.  Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci. 1999;40:619–630
  78. Denk PO, Knorr M. Effect of heparin on human corneal fibroblast proliferation in vitro with and without growth factor stimulation. Graefes Arch Clin Exp Ophthalmol. 1999;237:342–347
  79. Deuel TF, Senior RM, Chang D, et al.  Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci USA. 1981;78:4584–4587
  80. Dhein J, Walczak H, Baumler C, et al.  Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature. 1995;373:438–441
  81. Diegelmann RF, Kim JC, Lindblad WJ, et al.  Collection of leukocytes, fibroblasts, and collagen within an implantable reservoir tube during tissue repair. J Leukocyte Biol. 1987;42:667–672
  82. Duke-Elder S, Ashton N. Action of cortisone on tissue reactions of inflammation and repair with speical reference to the eye. Br J Ophthalmol. 1951;35:695–707
  83. Duncan MR, Berman B. Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J Exp Med. 1985;162:516–527
  84. Duncan MR, Berman B. Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta. J Invest Dermatol. 1989;92:699–706
  85. Dvonch VM, Murphey RJ, Matsuoka J, Grotendorst GR. Changes in growth factor levels in human wound fluid. Surgery. 1992;112:18–23
  86. Ehrlich HP, Hunt TK. Effects of cortisone and vitamin A on wound healing. Ann Surg. 1968;167:324–328
  87. Eisinger DR, Sheil AG. A comparison of the effects of cyclosporin A and standard agents on primary wound healing in the rat. Surg Gynecol Obstetr. 1999;160:135–138
  88. Elder MJ. The role of cytokines in chronic progressive conjunctival cicatrisation. Develop Ophthalmol. 1997;28:159–175
  89. Elder MJ, Bernauer W, Leonard J, Dart JK. Progression of disease in ocular cicatricial pemphigoid. Br J Ophthalmol. 1996;80:292–296
  90. Elder MJ, Dart JK, Lightman S. Conjunctival fibrosis in ocular cicatricial pemphigoid—the role of cytokines. Exp Eye Res. 1997;65:165–176
  91. Elias JA, Freundlich B, Kern JA, Rosenbloom J. Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest. 1990;97:1439–1445
  92. Ellis DG, Cheng Q, Lee DA. The effects of growth factors on Tenon's capsule fibroblasts in serum-free culture. Curr Eye Res. 1996;15:27–35
  93. Esser P, Heimann K, Wiedemann P. Macrophages in proliferative vitreoretinopathy and proliferative diabetic retinopathy (differentiation of subpopulations). Br J Ophthalmol. 1993;77:731–733
  94. Fahey TJ, Sherry B, Tracey KJ, et al.  Cytokine production in a model of wound healing (the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1). Cytokine. 1990;2:92–99
  95. Fauci AS. Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and B lymphocytes to the bone marrow. Immunology. 1975;28:669–680
  96. Fauci AS, Dale DC, Balow JE. Glucocorticosteroid therapy (mechanisms of action and clinical considerations). Ann Intern Med. 1976;84:304–315
  97. Ferguson TA, Griffith TS. A vision of cell death (insights into immune privilege). Immunol Rev. 1997;156:167–184
  98. Filipec M, Phan TM, Zhoa T-Z, et al.  Topical cyclosporine A and corneal wound healing. Cornea. 1992;11:546–552
  99. Fishel R, Barbul A, Wasserkrug HL, et al.  Cyclosporine A impairs wound healing in rats. J Surg Res. 1983;34:572–575
  100. Fishel RS, Barbul A, Beschorner WE, et al.  Lymphocyte participation in wound healing. Morphologic assessment using monoclonal antibodies. Ann Surg. 1987;206:25–29
  101. Ford HR, Hoffman RA, Wing EJ, et al.  Characterization of wound cytokines in the sponge matrix model. Arch Surg. 1989;124:1422–1428
  102. Forsberg E, Pejler G, Ringvall M, et al.  Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Nature. 1999;400:773–776
  103. Foster CS. Cicatricial pemphigoid. Trans Am Ophthalmol Soc. 1986;84:527–663
  104. Foxwell BM, Simon J, Herrero JJ, et al.  Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin A. Immunology. 1990;69:104–109
  105. Frank MM, Fries LF. The role of complement in inflammation and phagocytosis. Immunol Today. 1991;12:322–326
  106. Frasca L, Carmichael P, Lechler R, Lombardi G. Anergic T cells effect linked suppression. Eur J Immunol. 1997;27:3191–3197
  107. Fukasawa M, Bryant SM, Nakamura RM, diZerega GS. Modulation of fibroblast proliferation by postsurgical macrophages. J Surg Res. 1987;43:513–520
  108. Gamble JR, Harlan JM, Klebanoff SJ, Vadas MA. Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci USA. 1985;82:8667–8671
  109. Genestier L, Kasibhatla S, Brunner T, Green DR. Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc. J Exp Med. 1999;189:231–239
  110. Giangiacomo J, Dueker DK, Adelstein E. The effect of preoperative subconjunctival triamcinolone administration on glaucoma filtration. I. Trabeculectomy following subconjunctival triamcinolone. Arch Ophthalmol. 1986;104:838–841
  111. Giangiacomo J, Dueker DK, Adelstein EH. Histopathology of triamcinolone in the subconjunctiva. Ophthalmology. 1987;94:149–153
  112. Gillery P, Coustry F, Pujol JP, Borel JP. Inhibition of collagen synthesis by interleukin-1 in three-dimensional collagen lattice cultures of fibroblasts. Experientia. 1989;45:98–101
  113. Gillies M, Su T, Sarossy M, Hollows F. Interferon-alpha 2b inhibits proliferation of human Tenon's capsule fibroblasts. Graefes Arch Clin Exp Ophthalmol. 1993;231:119–121
  114. Gillies MC, Brooks AM, Young S, et al.  A randomized phase II trial of interferon-alpha2b versus 5-fluorouracil after trabeculectomy. Aust NZ J Ophthalmol. 1999;27:37–44
  115. Gillies MC, Goldberg I, Young SH, Su T. Glaucoma filtering surgery with interferon-α-2b. J Glaucoma. 1993;2:229–235
  116. Gombert W, Borthwick NJ, Wallace DL, et al.  Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation (a selective effect on Bcl-XL expression). Immunology. 1996;89:397–404
  117. Goss AN. Intra-uterine healing of fetal rat oral mucosal, skin and cartilage wounds. J Oral Pathol. 1977;6:35–43
  118. Gwynn DR, Stewart WC, Hennis HL, et al.  The influence of age upon inflammatory cell counts and structure of conjunctiva in chronic open-angle glaucoma. Acta Ophthalmologica. 1993;71:691–695
  119. Gwynn DR, Stewart WC, Pitts RA, et al.  Conjunctival structure and cell counts and the results of filtering surgery. Am J Ophthalmol. 1993;116:464–468
  120. Heufelder A, Bahn R. Modulation of Graves' orbital fibroblast proliferation by cytokines and glucocorticoid receptor agonists. Invest Ophthalmol Vis Sci. 1994;35:120–127
  121. Hingorani M, Calder VL, Buckley RJ, Lightman S. The immunomodulatory effect of topical cyclosporin in atopic keratoconjunctivitis. Invest Ophthalmol Vis Sci. 1999;40:392–399
  122. Hitchings RA, Grierson I. Clinicopathological correlation in eyes with failed fistulizing surgery. Trans Ophthalmol Soc UK. 1983;103:84–88
  123. Holland EJ, Olsen TW, Ketcham JM, et al.  Topical cyclosporin A in the treatment of anterior segment inflammatory disease. Cornea. 1993;12:413–419
  124. Hopkinson-Woolley J, Hughes D, Gordon S, Martin P. Macrophage recruitment during limb development and wound healing in the embryonic and fetal mouse. J Cell Sci. 1994;107:1159–1167
  125. Hubner G, Brauchle M, Smola H, et al.  Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. Cytokine. 1996;8:548–556
  126. Humphries DE, Wong GW, Friend DS, et al.  Heparin is essential for the storage of specific granule proteases in mast cells. Nature. 1999;400:769–772
  127. Hunt TK, Knighton DR, Thakral KK, et al.  Studies on inflammation and wound healing (angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophages). Surgery. 1984;96:48–54
  128. Hyde H, Borthwick NJ, Janossy G, et al.  Upregulation of intracellular glutathione by fibroblast-derived factor(s) (enhanced survival of activated T cells in the presence of low Bcl-2). Blood. 1997;89:2453–2460
  129. Issekutz TB, Issekutz AC, Movat HZ. The in vivo quantitation and kinetics of monocyte migration into acute inflammatory tissue. Am J Pathol. 1981;103:47–55
  130. Jay JL, Allan D. The benefit of early trabeculectomy versus conventional management in primary open angle glaucoma relative to severity of disease. Eye. 1989;3:528–535
  131. Jimenez SA, Freundlich B, Rosenbloom J. Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest. 1984;74:1112–1116
  132. Kahan A, Amor B, Menkes CJ, Strauch G. Recombinant interferon-gamma in the treatment of systemic sclerosis. Am J Med. 1989;87:273–277
  133. Kampik A, Kenyon KR, Michels RG, et al.  Epiretinal and vitreous membranes. Arch Ophthalmol. 1981;99:1445–1454
  134. Kaplan AP. Hageman factor-dependent pathways (mechanism of initiation and bradykinin formation). Federation Proc. 1983;42:3123–3127
  135. Kaushansky K, Lin N, Adamson JW. Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. J Clin Invest. 1988;81:92–97
  136. Kehrl JH, Wakefield LM, Roberts AB, et al.  Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986;163:1037–1050
  137. Khalil N, Bereznay O, Sporn M, Greenberg AH. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med. 1989;170:727–737
  138. Khaw PT, Occleston NL, Larkin G, et al.  The effects of growth factors on human ocular fibroblast proliferation, migration and collagen production. Invest Ophthalmol Vis Sci. 1994;35(Suppl):1898;[abstract]
  139. Khaw PT, Sherwood MB, MacKay SL, et al.  Five-minute treatments with fluorouracil, floxuridine, and mitomycin have long-term effects on human Tenon's capsule fibroblasts. Arch Ophthalmol. 1992;110:1150–1154
  140. Khaw PT, Ward S, Porter A, et al.  The long-term effects of 5-fluorouracil and sodium butyrate on human Tenon's fibroblasts. Invest Ophthalmol Vis Sci. 1992;33:2043–2052
  141. Kischer CW, Bunce H, Shetlah MR. Mast cell analyses in hypertrophic scars, hypertrophic scars treated with pressure and mature scars. J Invest Dermatol. 1978;70:355–357
  142. Knighton DR, Ciresi K, Fiegel VD, et al.  Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstetr. 1990;170:56–60
  143. Kossendrup D, Wiederholt M, Hoffman F. Influence of cyclosporin A, dexamethasone, and benzalkonium chloride (BAK) on corneal epithelial wound healing in the rabbit and guinea pig eye. Cornea. 1985;4:177–181
  144. Kronke M, Leonard WJ, Depper JM, et al.  Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci USA. 1984;81:5214–5218
  145. Krummel TM, Michna BA, Thomas BL, et al.  Transforming growth factor beta (TGF-beta) induces fibrosis in a fetal wound model. J Pediatric Surg. 1988;23:647–652
  146. Kupietzky A, Levi-Schaffer F. The role of mast cell-derived histamine in the closure of an in vitro wound. Inflammation Res. 1996;45:176–180
  147. Laato M, Heino J. Interleukin 1 modulates collagen accumulation by rat granulation tissue cells both in vivo and in vitro. Experientia. 1988;44:32–34
  148. Latina MA, Belmonte SJ, Park C, Crean E. Gamma-interferon effects on human fibroblasts from Tenon's capsule. Invest Ophthalmol Vis Sci. 1991;32:2806–2815
  149. Lawrence WT, Norton JA, Sporn MB, et al.  The reversal of an Adriamycin induced healing impairment with chemoattractants and growth factors. Ann Surg. 1986;203:142–147
  150. Leibovich SJ, Polverini PJ, Shepard HM, et al.  Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Nature. 1987;329:630–632
  151. Leibovich SJ, Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol. 1975;78:71–100
  152. Leibovich SJ, Ross R. A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro. Am J Pathol. 1976;84:501–514
  153. Leonardi A, Radice M, Fregona IA, et al.  Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis. Exp Eye Res. 1999;68:739–746
  154. Levi-Schaffer F, Kupietzky A. Mast cells enhance migration and proliferation of fibroblasts into an in vitro wound. Exp Cell Res. 1990;188:42–49
  155. Levine JH, Moses HL, Gold LI, Nanney LB. Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair. Am J Pathol. 1993;143:368–380
  156. Limb GA, Franks WA, Munasinghe KR, et al.  Proliferative vitreoretinopathy (an examination of the involvement of lymphocytes, adhesion molecules and HLA-DR antigens). Graefes Arch Clin Exp Ophthalmol. 1993;231:331–336
  157. Limb GA, Little BC, Meager A, et al.  Cytokines in proliferative vitreoretinopathy. Eye. 1991;5:686–693
  158. Malawista SE, Montgomery RR, van BG. Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes. J Clin Invest. 1992;90:631–636
  159. Marrack P, Kappler J, Mitchell T. Type I Interferons Keep Activated T cells Alive. J Exp Med. 1999;189:521–529
  160. Martin CW, Muir IF. The role of lymphocytes in wound healing. Br J Plastic Surg. 1990;43:655–662
  161. Martin P. Wound healing-aiming for perfect skin regeneration. Science. 1997;276:75–81
  162. McMillan TA, Stewart WC, Hennis HL, et al.  Histologic differences in the conjunctiva of black and white glaucoma patients. Ophthalmic Surg. 1992;23:762–765
  163. Migdal C, Hitchings R. The developing bleb (effect of topical antiprostaglandins on the outcome of glaucoma fistulising surgery). Br J Ophthalmol. 1983;67:655–660
  164. Migdal C, Hitchings R. Control of chronic simple glaucoma with primary medical, surgical and laser treatment. Trans Ophthalmol Soc UK. 1986;105:653–656
  165. Miller MH, Grierson I, Unger WG, Hitchings RA. The effect of topical dexamethasone and preoperative beta irradiation on a model of glaucoma fistulizing surgery in the rabbit. Ophthalmic Surg. 1990;21:44–54
  166. Miller MH, Grierson I, Unger WI, Hitchings RA. Wound healing in an animal model of glaucoma fistulizing surgery in the rabbit. Ophthalmic Surg. 1989;20:350–357
  167. Molteno AC, Straughan JL, Ancker E. Control of bleb fibrosis after glaucoma surgery by anti-inflammatory agents. S African Med J. 1976;50:881–885
  168. Mustoe TA, Pierce GF, Thomason A, et al.  Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science. 1987;237:1333–1336
  169. Mustoe TA, Purdy J, Gramates P, et al.  Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB. Am J Surg. 1989;158:345–350
  170. Nguyen KD, Hoang AT, Lee DA. Transcriptional control of human Tenon's capsule fibroblast collagen synthesis in vitro by gamma-interferon. Invest Ophthalmol Vis Sci. 1994;35:3064–3070
  171. Nielson EG, Phillips SM, Jimenez S. Lymphokine modulation of fibroblast proliferation. J Immunol. 1982;128:1484–1486
  172. Nishida T, Tanaka H, Nakagawa S, et al.  Fibronectin synthesis by the rabbit cornea (effects of mouse epidermal growth factor and cyclic AMP analogs). Jpn J Ophthalmol. 1984;28:196–202
  173. Nuzzi R, Cerruti A, Finazzo C. Cyclosporine C (a study of wound-healing modulation after trabeculectomy in rabbit). Acta Ophthalmol Scand. 1998;Suppl:48–49
  174. Nuzzi R, Vercelli A, Finazzo C, Cracco C. Conjunctiva and subconjunctival tissue in primary open-angle glaucoma after long-term topical treatment (an immunohistochemical and ultrastructural study). Graefes Arch Clin Exp Ophthalmol. 1995;233:154–162
  175. O'Brien TP, Li Q, Ashraq F, et al.  Inflammatory Response in the Early Stages of Wound Healing after Excimer Laser Keratectomy. Arch Ophthalmol. 1998;116:1470–1474
  176. Occleston NL, Alexander RA, Mazure A, et al.  Effects of single exposures to antiproliferative agents on ocular fibroblast-mediated collagen contraction. Invest Ophthalmol Vis Sci. 1994;35:3681–3690
  177. Occleston NL, Daniels JT, Tarnuzzer RW, et al.  Single exposures to antiproliferatives (long-term effects on ocular fibroblast wound-healing behaviour). Invest Ophthalmol Vis Sci. 1997;38:1998–2007
  178. Olutoye OO, Yager DR, Cohen IK, Diegelmann RF. Lower cytokine release by fetal porcine platelets (a possible explanation for reduced inflammation after fetal wounding). J Pediatric Surg. 1996;31:91–95
  179. Oster W, Lindemann A, Horn S, et al.  Tumor necrosis factor (TNF)-alpha but not TNF-beta induces secretion of colony stimulating factor for macrophages (CSF-1) by human monocytes. Blood. 1987;70:1700–1703
  180. Pasquale LR, Dorman-Pease ME, Lutty GA, et al.  Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1993;34:23–30
  181. Pasquale LR, Thibault D, Dorman-Pease ME, et al.  Effect of topical mitomycin C on glaucoma filtration surgery in monkeys. Ophthalmology. 1992;99:14–18
  182. Patten JT, Cavanagh HD, Allansmith MR. Induced ocular pseudopemphigoid. Am J Ophthalmol. 1976;82:272–276
  183. Peterson JM, Barbul A, Breslin RJ, et al.  Significance of T-lymphocytes in wound healing. Surgery. 1987;102:300–305
  184. Petri JB, Schurk S, Gebauer S, Haustein UF. Cyclosporine A delays wound healing and apoptosis and suppresses activin beta-A expression in rats. Eur J Dermatol. 1998;8:104–113
  185. Pierce GF, Brown D, Mustoe TA. Quantitative analysis of inflammatory cell influx, procollagen type I synthesis, and collagen cross-linking in incisional wounds (influence of PDGF-BB and TGF-beta 1 therapy). J Lab Clin Med. 1991;117:373–382
  186. Pierce GF, Mustoe TA, Lingelbach J, et al.  Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats (possible regulation in macrophages by platelet-derived growth factor). Proc Natl Acad Sci USA. 1989;86:2229–2233
  187. Pierce GF, Mustoe TA, Lingelbach J, et al.  Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J Cell Biol. 1989;109:429–440
  188. Pierce GF, Mustoe TA, Senior RM, et al.  In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins. J Exp Med. 1988;167:974–987
  189. Pierce GF, Tarpley JE, Yanagihara D, et al.  Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Neovessel and matrix formation and cessation of repair. Am J Pathol. 1992;140:1375–1388
  190. Pierce GF, Vande BJ, Rudolph R, et al.  Platelet-derived growth factor-BB and transforming growth factor beta 1 selectively modulate glycosaminoglycans, collagen, and myofibroblasts in excisional wounds. Am J Pathol. 1991;138:629–646
  191. Pilling D, Akbar AN, Girdlestone J, et al.  Interferon-beta mediates stromal cell rescue of T cells from apoptosis. Eur J Immunol. 1999;29:1041–1050
  192. Plemons JM, Dill RE, Rees TD, et al.  PDGF-B producing cells and PDGF-B gene expression in normal gingival and cyclopsorin-induced overgrowth. J Periodontol. 1996;67:264–270
  193. Postlethwaite AE, Holness MA, Katai H, Raghow R. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest. 1992;90:1479–1485
  194. Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med. 1987;165:251–256
  195. Postlethwaite AE, Seyer JM. Fibroblast chemotaxis induction by human recombinant interleukin-4. Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70–88 and 89–122. J Clin Invest. 1991;87:2147–2152
  196. Postlethwaite AE, Smith GN, Mainardi CL, et al.  Lymphocyte modulation of fibroblast function in vitro (stimulation and inhibition of collagen production by different effector molecules). J Immunol. 1984;132:2470–2477
  197. Pouliquen Y, Patey A, Foster CS, et al.  Drug-induced cicatricial pemphigoid affecting the conjunctiva. Light and electron microscopic features. Ophthalmology. 1986;93:775–783
  198. Quaglino DJ, Nanney LB, Ditesheim JA, Davidson JM. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin (incisional wound model). J Invest Dermatol. 1991;97:34–42
  199. Reichel MB, Cordeiro MF, Alexander RA, et al.  New model of conjunctival scarring in the mouse eye. Br J Ophthalmol. 1998;82:1072–1077
  200. Rice BA, Foster CS. Immunopathology of cicatricial pemphigoid affecting the conjunctiva. Ophthalmology. 1990;97:1476–1483
  201. Roberts AB, Sporn MB, Assoian RK, et al.  Transforming growth factor type beta (rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro). Proc Natl Acad Sci USA. 1986;83:4167–4171
  202. Robinson DI, Lertsumitkul S, Billson FA, Robinson LP. Long-term intraocular pressure control by trabeculectomy (a ten-year life table). Aust NZ J Ophthalmol. 1993;21:79–85
  203. Rosenbloom J, Feldman G, Freundlich B, Jimenez SA. Inhibition of excessive scleroderma fibroblast collagen production by recombinant gamma-interferon. Association with a coordinate decrease in types I and III procollagen messenger RNA levels. Arthritis Rheum. 1986;29:851–856
  204. Rossi P, Karsenty G, Roberts AB, et al.  A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell. 1988;52:405–414
  205. Roth SM, Spaeth GL, Starita RJ, et al.  The effects of postoperative corticosteroids on trabeculectomy and the clinical course of glaucoma (five-year follow-up study). Ophthalmic Surg. 1991;22:724–729
  206. Roumm AD, Whiteside TL, Medsger TAJ, Rodnan GP. Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations. Arthritis Rheum. 1984;27:645–653
  207. Sacks EH, Jakobiec FA, Wieczorek R, et al.  Immunophenotypic analysis of the inflammatory infiltrate in ocular cicatricial pemphigoid. Further evidence for a T cell-mediated disease. Ophthalmology. 1989;96:236–243
  208. Sacks EH, Wieczorek R, Jakobiec FA, Knowles DM. Lymphocytic subpopulations in the normal human conjunctiva. A monoclonal antibody study. Ophthalmology. 1986;93:1276–1283
  209. Salmon M, Scheel-Toellner D, Huissoon AP, et al.  Inhibition of T cell apoptosis in the rheumatoid synovium. J Clin Invest. 1997;99:439–446
  210. Schmidt J, Fleissner S, Heimann-Weitschat I, et al.  Effect of corticosteroids, cyclosporin A, and methotrexate on cytokine release from monocytes and T-cell subsets. Immunopharmacology. 1994;27:173–179
  211. Schultz G, Khaw PT, Oxford K, et al.  Growth factors and ocular wound healing. Eye. 1994;8:184–187
  212. Schwab IR, Linberg JV, Gioia VM, et al.  Foreshortening of the inferior conjunctival fornix associated with chronic glaucoma medications. Ophthalmology. 1992;99:197–202
  213. Scudeletti M, Pende D, Barabino A, et al.  Effect of single oral doses of prednisone and deflazacort on human lymphocyte distribution and functions. Analysis with monoclonal antibodies. Adv Exp Med Biol. 1984;171:335–344
  214. Secchi AG, Tognon MS, Leonardi A. Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol. 1990;110:641–645
  215. Seetner A, Morin JD. Healing of trabeculectomies in rabbits. Can J Ophthalmol. 1979;14:121–125
  216. Selman M, Gonzalez G, Bravo M, et al.  Effect of lung T lymphocytes on fibroblasts in idiopathic pulmonary fibrosis and extrinsic allergic alveolitis. Thorax. 1990;45:451–455
  217. Serini G, Gabbiani G. Modulation of alpha-smooth muscle actin expression in fibroblasts by TGF-beta. Wound Repair Regeneration. 1996;4:278
  218. Shah M, Foreman DM, Ferguson MW. Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta. Lancet. 1992;339:213–214
  219. Shah M, Foreman DM, Ferguson MW. Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents. J Cell Sci. 1994;107:1137–1157
  220. Shah M, Foreman DM, Ferguson MW. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci. 1995;108:985–1002
  221. Shahar I, Fireman E, Topilsky M, et al.  Effect of IL-6 on alveolar fibroblast proliferation in interstitial lung diseases. Clin Immunol Immunopathol. 1996;79:244–251
  222. Sherwood MB, Grierson I, Millar L, Hitchings RA. Long-term morphologic effects of antiglaucoma drugs on the conjunctiva and Tenon's capsule in glaucomatous patients. Ophthalmology. 1989;96:327–335
  223. Shields MB, Scroggs MW, Sloop CM, Simmons RB. Clinical and histopathologic observations concerning hypotony after trabeculectomy with adjunctive mitomycin C. Am J Ophthalmol. 1993;116:673–683
  224. Shipley GD, Keeble WW, Hendrickson JE, et al.  Growth of normal human keratinocytes and fibroblasts in serum-free medium is stimulated by acidic and basic fibroblast growth factor. J Cell Physiol. 1989;138:511–518
  225. Simpson DM, Ross R. The neutrophilic leukocyte in wound repair a study with antineutrophil serum. J Clin Invest. 1972;51:2009–2023
  226. Skuta GL, Beeson CC, Higginbotham EJ, et al.  Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. Ophthalmology. 1992;99:438–444
  227. Smith DL, Skuta GL, Kincaid MC, et al.  The effects of glaucoma medications on Tenon's capsule and conjunctiva in the rabbit. Ophthalmic Surg. 1991;22:336–340
  228. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration (the multistep paradigm). Cell. 1994;76:301–314
  229. Sprugel KH, McPherson JM, Clowes AW, Ross R. Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers. Am J Pathol. 1987;129:601–613
  230. Starita RJ, Fellman RL, Spaeth GL, et al.  Short- and long-term effects of postoperative corticosteroids on trabeculectomy. Ophthalmology. 1985;92:938–946
  231. Sugar HS. Clinical effect of corticosteroids on conjunctival filtering blebs; a case report. Am J Ophthalmol. 1965;59:854–860
  232. Thornton SC, Por SB, Walsh BJ, et al.  Interaction of immune and connective tissue cells (I. The effect of lymphokines and monokines on fibroblast growth). J Leukocyte Biol. 1990;47:312–320
  233. Tonnesen MG, Smedly LA, Henson PM. Neutrophil-endothelial cell interactions. Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro. J Clin Invest. 1984;74:1581–1592
  234. Tripathi RC, Li J, Chan WF, Tripathi BJ. Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp Eye Res. 1994;59:723–727
  235. Van Story-Lewis PE, Tenenbaum HC. Glucocorticoid inhibition of fibroblast contraction of collagen gels. Biochem Pharmacol. 1986;35:1283–1286
  236. Vilcek J, Palombella VJ, Henriksen-DeStefano D, et al.  Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J Exp Med. 1986;163:632–643
  237. Wahl SM, Gately CL. Modulation of fibroblast growth by a lymphokine of human T cell continuous T cell line origin. J Immunol. 1983;130:1226–1230
  238. Wahl SM, Hunt DA, Wakefield LM, et al.  Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA. 1987;84:5788–5792
  239. Wahl SM, Wahl LM, McCarthy JB. Lymphocyte-mediated activation of fibroblast proliferation and collagen production. J Immunol. 1978;121:942–946
  240. Wang JM, Griffin JD, Rambaldi A, et al.  Induction of monocyte migration by recombinant macrophage colony-stimulating factor. J Immunol. 1988;141:575–579
  241. Wedmore CV, Williams TJ. PAF, a scretory product of polymorphonuclear leukocytes, increases vascular permeability in rabbit skin. Br J Pharmacol. 1981;74:916–917
  242. Weinreb RN. Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects. Ophthalmology. 1987;94:564–570
  243. Westergren-Thorsson G, Antonsson P, Malmstrom A, et al.  The synthesis of a family of structurally related proteoglycans in fibroblasts is differently regulated by TFG-beta. Matrix. 1991;11:177–183
  244. Williams DE, Nguyen KD, Shapourifar-Tehrani S, et al.  Effects of timolol, betaxolol, and levobunolol on human tenon's fibroblasts in tissue culture. Invest Ophthalmol Vis Sci. 1992;33:2233–2241
  245. Wing EJ, Ampel NM, Waheed A, Shadduck RK. Macrophage colony-stimulating factor (M-CSF) enhances the capacity of murine macrophages to secrete oxygen reduction products. J Immunol. 1985;135:2052–2056
  246. Wiseman DM, Polverini PJ, Kamp DW, Leibovich SJ. Transforming growth factor-beta (TGF beta) is chemotactic for human monocytes and induces their expression of angiogenic activity. Biochem Biophys Res Comm. 1988;157:793–800
  247. Witte MB, Barbul A. General principles of wound healing. Surg Clin N Am. 1997;77:509–528
  248. Woods AC. Clinical and experimental observation on the use of ACTH and cortisone in ocular inflammatory disease. Am J Ophthalmol. 1950;33:1325–1349

☆ The authors have no proprietary or commercial interest in any product or idea discussed in this article.

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Survey of Ophthalmology
Volume 45, Issue 1 , Pages 49-68 , 15 July 2000

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