Survey of Ophthalmology
Volume 45 , Pages S211-S220 , March 2001

The Pathology of Dry Eye

  • Christophe Baudouin, MD

      Affiliations

    • Corresponding Author InformationReprint address: Professor Christophe Baudouin, Centre Hospitalier National d'Ophthalmologie des Quinze-Vingts, Service d'Ophthalmologie III, 28 rue de Charenton, 75012, Paris, France

References 

  1. Albietz JM, Golding TR. Differential diagnosis and management of common dry eye subtypes. Clin Exp Optom. 1994;77:244–260
  2. Azzarolo AM, Bjerrum K, Maves CA, et al.  Hypophysectomy-induced regression of female rat lacrimal glands (partial restoration and maintenance by dihydrotestosterone and prolactin). Invest Ophthalmol Vis Sci. 1995;36:216–226
  3. Azzarolo AM, Mircheff AK, Kaswan RL, et al.  Androgen support of lacrimal gland function. Endocrine. 1997;6:39–45
  4. Bacman S, Perez Leiros C, Sterin-Borda L, et al.  Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjogrens syndrome. Invest Ophthalmol Vis Sci. 1998;39:151–156
  5. Baudouin C, Brignole F, Becquet F, et al.  Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation. Invest Ophthalmol Vis Sci. 1997;38:1458–1464
  6. Baudouin C, Haouat N, Brignole F, et al.  Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens. Br J Ophthalmol. 1992;76:545–549
  7. Baudouin C, Pisella PJ, Fillacier K, et al.  Ocular surface inflammatory changes induced by topical antiglaucoma drugs (human and animal studies). Ophthalmology. 1999;106:556–563[see comments]
  8. Becquet F, Goldschild M, Moldovan MS, et al.  Histopathological effects of topical ophthalmic preservatives on rat corneoconjunctival surface. Curr Eye Res. 1998;17:419–425
  9. Brandt JD, Wittpenn JR, Katz LJ, et al.  Conjunctival impression cytology in patients with glaucoma using long- term topical medication. Am J Ophthalmol. 1991;112:297–301
  10. Brignole F, De Saint-Jean M, Goldschild M, et al.  Expression of Fas-Fas ligand antigens and apoptotic marker APO2.7 by the human conjunctival epithelium. Positive correlation with class II HLA DR expression in inflammatory ocular surface disorders. Exp Eye Res. 1998;67:687–697
  11. Brignole F, Pisella PJ, Goldschild M, et al.  Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest Ophthalmol Vis Sci. 2000;41:1356–1363
  12. Broadway DC, Grierson I, OBrien C, Hitchings RA. Adverse effects of topical antiglaucoma medication. I. The conjunctival cell profile. Arch Ophthalmol. 1994;112:1437–1445
  13. Bron AJ. Diagnosis of dry eye. Surv Ophthalmol. 2001;45(Suppl):S221–S226
  14. Burstein NL. Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. Surv Ophthalmol. 1980;25:15–30
  15. Cohn L, Homer RJ, Niu N, Bottomly K. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med. 1999;190:1309–1318
  16. Damato BE, Allan D, Murray SB, Lee WR. Senile atrophy of the human lacrimal gland (the contribution of chronic inflammatory disease). Br J Ophthalmol. 1984;68:674–680
  17. Darmon AJ, Nicholson DW, Bleackley RC. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature. 1995;377:446–448
  18. Dartt DA, Kessler TL, Chung EH, Zieske JD. Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells. Exp Eye Res. 1996;63:27–34
  19. Dartt DA, McCarthy DM, Mercer HJ, et al.  Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr Eye Res. 1995;14:993–1000
  20. De Saint Jean M, Brignole F, Bringuier AF, et al.  Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci. 1999;40:619–630
  21. De Saint Jean M, Brignole F, Feldmann G, et al.  Interferon-gamma induces apoptosis and expression of inflammation-related proteins in Chang conjunctival cells. Invest Ophthalmol Vis Sci. 1999;40:2199–2212
  22. Esmaeli B, Harvey JT, Hewlett B. Immunohistochemical evidence for estrogen receptors in meibomian glands. Ophthalmology. 2000;107:180–184
  23. Fox PC, Speight PM. Current concepts of autoimmune exocrinopathy (immunologic mechanisms in the salivary pathology of Sjogrens syndrome). Crit Rev Oral Biol Med. 1996;7:144–158
  24. Fox RI. Sjogrens syndrome. Pathogenesis and new approaches to therapy. Adv Exp Med Biol. 1998;438:891–902
  25. Fujihara T, Fujita H, Tsubota K, et al.  Preferential localization of CD8+ alpha E beta 7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogrens syndrome. J Immunol. 1999;163:2226–2235
  26. Gao J, Schwalb TA, Addeo JV, et al.  The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca (the effect of topical Cyclosporin A therapy). Cornea. 1998;17:654–663
  27. Gasset AR, Ishii Y, Kaufman HE, Miller T. Cytotoxicity of ophthalmic preservatives. Am J Ophthalmol. 1974;78:98–105
  28. Gilbard JP. Dry eye, blepharitis and chronic eye irritation (divide and conquer). J Ophthalmic Nurs Technol. 1999;18:109–115
  29. Hajjar C, Sainte-Foie S, Savin J, et al: [HTLV1 infection and sicca syndrome]. J Fr Ophtalmol 18: 597-602, 1995
  30. Herreras JM, Pastor JC, Calonge M, Asensio VM. Ocular surface alteration after long-term treatment with an antiglaucomatous drug. Ophthalmology. 1992;99:1082–1088[see comments]
  31. Iwata M, Kiritoshi A, Roat MI, et al.  Regulation of HLA class II antigen expression on cultured corneal epithelium by interferon-gamma. Invest Ophthalmol Vis Sci. 1992;33:2714–2721
  32. Jones DT, Monroy D, Ji Z. Sjögrens syndrome (cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium). Invest Ophthalmol Vis Sci. 1994;350:583–593
  33. Jones DT, Monroy D, Ji Z, Pflugfelder SC. Alterations of ocular surface gene expression in Sjogrens syndrome. Adv Exp Med Biol. 1998;438:533–536
  34. Lee SH, Tseng SC. Rose bengal staining and cytologic characteristics associated with lipid tear deficiency. Am J Ophthalmol. 1997;124:736–750
  35. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995;21:221–232
  36. McCartney-Francis NL, Mizel DE, Frazier-Jessen M, et al.  Lacrimal gland inflammation is responsible for ocular pathology in TGF- beta 1 null mice. Am J Pathol. 1997;151:1281–1288
  37. Meneray MA, Fields TY, Bennett DJ. Gi/Go couple met-enkephalin to inhibition of cholinergic and beta- adrenergic stimulation of lacrimal secretion. Cornea. 2000;19:92–98
  38. Mietz H, Niesen U, Krieglstein GK. The effect of preservatives and antiglaucomatous medication on the histopathology of the conjunctiva. Graefes Arch Clin Exp Ophthalmol. 1994;232:561–565
  39. Mircheff AK, Gierow JP, Yang T, et al.  Sjogrens autoimmunity (how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface). J Mol Recognit. 1998;11:40–48
  40. Mircheff AK, Gierow JP, Wood RL. Traffic of major histocompatibility complex class II molecules in rabbit lacrimal gland acinar cells. Invest Ophthalmol Vis Sci. 1994;35:3943–3951
  41. Nikkinen A, Uusitalo H, Lehtosalo JI, Palkama A. Distribution of adrenergic nerves in the lacrimal glands of guinea-pig and rat. Exp Eye Res. 1985;40:751–756
  42. Pflugfelder SC, Crouse C, Pereira I, Atherton S. Amplification of Epstein-Barr virus genomic sequences in blood cells, lacrimal glands, and tears from primary Sjogrens syndrome patients. Ophthalmology. 1990;97:976–984
  43. Raskin EM, Speaker MG, Laibson PR. Blepharitis. Infect Dis Clin North Am. 1992;6:777–787
  44. Rocha EM, Wickham LA, da Silveira LA, et al.  Identification of androgen receptor protein and 5alpha-reductase mRNA in human ocular tissues. Br J Ophthalmol. 2000;84:76–84
  45. Schaumberg DA, Sullivan DA, Buring JE, Dana MR: Hormone replacement therapy and the prevalence of dry eye symptoms. Presented at ARVO 2000, Fort Lauderdale, Florida, USA, 4 May 2000
  46. Schoenwald RD, Barfknecht CF, Shirolkar S, Xia E. The effects of sigma ligands on protein release from lacrimal acinar cells (a potential agonist/antagonist assay). Life Sci. 1995;56:1275–1285
  47. Seifert P, Spitznas M. Immunocytochemical and ultrastructural evaluation of the distribution of nervous tissue and neuropeptides in the meibomian gland. Graefes Arch Clin Exp Ophthalmol. 1996;234:648–656
  48. Seifert P, Stuppi S, Spitznas M, Weihe E. Differential distribution of neuronal markers and neuropeptides in the human lacrimal gland. Graefes Arch Clin Exp Ophthalmol. 1996;234:232–240
  49. Shimazaki J, Sakata M, Tsubota K. Ocular surface changes and discomfort in patients with meibomian gland dysfunction. Arch Ophthalmol. 1995;113:1266–1270
  50. Singh J, Djali PK, Adeghate E. Immunohistochemistry and secretory effects of leucine enkephalin in the isolated pig lacrimal gland. Adv Exp Med Biol. 1998;438:157–161
  51. Stern ME, Beuerman RW, Fox RI, et al.  The pathology of dry eye (the interaction between the ocular surface and lacrimal glands). Cornea. 1998;17:584–589
  52. Sullivan DA, Block L, Pena JD. Influence of androgens and pituitary hormones on the structural profile and secretory activity of the lacrimal gland. Acta Ophthalmol Scand. 1996;74:421–435
  53. Sullivan DA, Edwards JA. Androgen stimulation of lacrimal gland function in mouse models of Sjogrens syndrome. J Steroid Biochem Mol Biol. 1997;60:237–245
  54. Sullivan DA, Edwards JA, Wickham LA, et al.  Identification and endocrine control of sex steroid binding sites in the lacrimal gland. Curr Eye Res. 1996;15:279–291
  55. Sullivan DA, Krenzer KL, Sullivan BD, et al.  Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?. Invest Ophthalmol Vis Sci. 1999;40:1261–1265
  56. Sullivan DA, Rocha EM, Ullman MD, et al.  Androgen regulation of the meibomian gland. Adv Exp Med Biol. 1998;438:327–331
  57. Sullivan DA, Wickham LA, Rocha EM, et al.  Influence of gender, sex steroid hormones, and the hypothalamic- pituitary axis on the structure and function of the lacrimal gland. Adv Exp Med Biol. 1998;438:11–42
  58. Sullivan DA, Wickham LA, Rocha EM, et al.  Androgens and dry eye in Sjogrens syndrome. Ann NY Acad Sci. 1999;876:312–324
  59. Tabbara K, Sharara N. Sjogrens syndrome (pathogenesis). Eur J Ophthalmol. 1999;9:1–7
  60. Toda I, Shimazaki J, Tsubota K. Dry eye with only decreased tear break-up time is sometimes associated with allergic conjunctivitis. Ophthalmology. 1995;102:302–309
  61. Tsubota K, Fukagawa K, Fujihara T, et al.  Regulation of human leukocyte antigen expression in human conjunctival epithelium. Invest Ophthalmol Vis Sci. 1999;40:28–34
  62. Tsubota K, Xu KP, Fujihara T, et al.  Decreased reflex tearing is associated with lymphocytic infiltration in lacrimal glands. J Rheumatol. 1996;23:313–320
  63. Wickham LA, Gao J, Toda I. Identification of androgen, estrogen and progesterone receptor mRNAs in the eye. Acta Ophthalmol Scand. 2000;78:146–153
  64. Williamson J, Gibson AA, Wilson T, et al.  Histology of the lacrimal gland in keratoconjunctivitis sicca. Br J Ophthalmol. 1973;57:852–858
  65. Yoshino K, Monroy D, Pflugfelder SC. Cholinergic stimulation of lactoferrin and epidermal growth factor secretion by the human lacrimal gland. Cornea. 1996;15:617–621[see comments]
  66. Zoukhri D, Hodges RR, Dartt DA. Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjogrens syndrome. Clin Immunol Immunopathol. 1998;89:126–133
  67. Zoukhri D, Hodges RR, Dicker DM, Dartt DA. Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion. FEBS Lett. 1994;351:67–72
  68. Zoukhri D, Hodges RR, Rawe IM, Dartt DA. Ca2+ signaling by cholinergic and alpha1-adrenergic agonists is up-regulated in lacrimal and submandibular glands in a murine model of Sjogrens syndrome. Clin Immunol Immunopathol. 1998;89:134–140

PII: S0039-6257(00)00200-9

Survey of Ophthalmology
Volume 45 , Pages S211-S220 , March 2001