Survey of Ophthalmology
Volume 45 , Pages S290-S294 , May 2001

Role of Alpha-2 Adrenergic Receptors in Neuroprotection and Glaucoma

References 

  1. Ahmed F, Hegazy K, Chaudhray P, Sharma S. Neuroprotective effect of brimonidine on adult rat retinal ganglion cells after increased intraocular pressure. Invest Ophthalmol Vis Sci. 1999;40(Suppl):S265;[abstract]
  2. Berlie JR, Iversen LJ, Blaxall HS, et al.  Alpha-2 adrenergic receptors in the bovine retina. Presence of only the alpha-. 1995;2D(subtype. Invest Ophthalmol Vis Sci 36):1885–1892
  3. Burke J, Manlapaz C, Kharlamb A, et al.  Therapeutic use of 2-adrenceptor agonists in glaucoma. In:  Lanier SM,  Limbird LE editor. Alpha-2-Adrenergic Receptors Structure, Function and Therapeutic Implications. Reading, UK: Harwood Academic Publishers; 1996;p. 179–187
  4. Bylund DB, Chacko DM. Characterization of alpha2 adrenergic receptor subtypes in human ocular tissue homogenates. Invest Ophthalmol Vis Sci. 1999;40:2299–2306
  5. Donello JE, Padillo EU, Webster ML, et al.  2-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia. J Pharmacol Exp Ther. 2001;296:216–223
  6. Ervin C, Wohabrebbi A, Iannaccone A, Jablonski M. Brimonidine rescues photoreceptors from degeneration induced by retinal pigment epithelium removal in vitro. Invest Ophthalmol Vis Sci. 1999;40(Suppl):S160;[abstract]
  7. Fritzsch B. Fast axonal diffusion of 3000 molecular weight dextran amines. J Neurosci Methods. 1993;50:95–103
  8. Hasson D, Lai R, Chun T, Wheeler L. Functional protection of rat retina from ischemic injury by brimonidine. Soc Neurosci Abstracts. 1997;23:168;[abstract]
  9. Hoffman WE, Kochs E, Werner C, et al.  Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha-. 1991;2-adrenergic(antagonist atipamezole. Anesthesiology 75):328–332
  10. Huang Y, Gil DW, Vanscheeuwijck P, et al.  Localization of alpha-2-adrenergic receptor subtypes in the anterior segment of the human eye with selective antibodies. Invest Ophthalmol Vis Sci. 1995;36:2729–2739
  11. Kent AR, Nussdorf JD, David R, et al.  Vitreous concentration of topically applied 0.2% brimonidine tartrate. Ophthalmology. 2001;108:784–787
  12. Kerrigan LA, Zack DJ, Quigley HA, et al.  TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch Ophthalmol. 1997;115:1031–1035
  13. Lai R, Chun T, Hasson D, Wheeler L. Activation of cell survival signaling pathway in the retina by selective apha-2 adrenoceptor agonist brimonidine. Invest Ophthalmol Vis Sci. 1999;40:S763;[abstract]
  14. Lai R, Chun T, Hasson D, et al.  Brimonidine protects photoreceptors and visual function after light damage. Invest Ophthalmol Vis Sci. 1998;39(Suppl):S876;[abstract]
  15. Levkovitch-Verbin H, Harris-Cerruti C, Groner Y, et al.  RGC death in mice after optic nerve crush injury (oxidative stress and neuroprotection). Invest Ophthalmol Vis Sci. 2000;41:4169–4174
  16. MacDonald E, Kobilka BK, Scheinin M. Gene targeting—homing in on alpha-2-adrenoceptor-subtype function. Trends Pharmacol Sci. 1997;18:211–219
  17. Maier C, Steinberg GK, Sun GH, et al.  Neuroprotection by the alpha-2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology. 1993;79:306–312
  18. Ruiz G, Wheeler L, WoldeMussie E, Schwartz M. Time course of pre or post treatment by brimonidine on neuroprotection in rat optic nerve injury model. Invest Ophthalmol Vis Sci. 2000;41(Suppl):S830;[abstract]
  19. Villegas-Perez M, Lafuente M, Mayor-Torroglosa S, et al.  Short and long term neuroprotection of a selective alpha-2 agonist (AGN 191103) on retinal ganglion cell survival after ischemia induced by selective ligature of the ophthalmic vessels. Invest Ophthalmol Vis Sci. 2000;41(Suppl):S14;[abstract]
  20. Wen R, Cheng T, Li Y, et al.  Alpha-2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. J Neurosci. 1996;16:5986–5992
  21. Wikberg-Matsson A, Wikberg JE, Uhlen S. Characterization of alpha-2-adrenoceptor subtypes in the porcine eye (identification of alpha-2A-adrenoceptors in the choroid, ciliary body and iris, and alpha-2A- and alpha-2C-adrenoceptors in the retina). Exp Eye Res. 1996;63:57–66
  22. Williams JT, North RA. Catecholamine inhibition of calcium action potentials in rat locus coeruleus neurones. Neuroscience. 1985;14:103–109
  23. WoldeMussie E, Ruiz G, Wijono M, Wheeler L. Neuroprotective effect of brimonidine in chronic ocular hypertensive rats. Invest Ophthalmol Vis Sci. 2000;41(Suppl):S830;[abstract]
  24. Yoles E, Wheeler L, Schwartz M. Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration. Invest Ophthalmol Vis Sci. 1999;40:65–73

PII: S0039-6257(01)00206-5

Survey of Ophthalmology
Volume 45 , Pages S290-S294 , May 2001

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