Survey of Ophthalmology
Volume 46, Issue 2 , Pages 164-171 , September 2001

Juvenile Xanthogranuloma Masquerading as Pediatric Chronic Uveitis: A Clinicopathologic Study

  • Ehud Zamir, MD

      Affiliations

    • Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA
    • ,
  • Robert C Wang, MD

      Affiliations

    • Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA
    • ,
  • Subramanian Krishnakumar, MD

      Affiliations

    • Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA
    • ,
  • Amy Aiello Leverant, MD

      Affiliations

    • Arizona Pediatric Eye Specialists, Phoenix, AZ USA
    • ,
  • Pravin U Dugel, MD

      Affiliations

    • Retinal Consultants of Arizona, Phoenix, AZ, USA
    • ,
  • Narsing A Rao, MD

      Affiliations

    • Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA
    • Corresponding Author InformationReprint address: Narsing A. Rao, MD, Doheny Eye Institute, University of Southern California, Keck School of Medicine, 1450 San Pablo Street, DVRC 211, Los Angeles, CA 90033.

References 

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  2. Andersen WK, Knowles DM, Silvers DN. CD1 (OKT6)-positive juvenile xanthogranuloma. OKT6 is not specific for Langerhans cell histiocytosis (histiocytosis X). J Am Acad Dermatol. 1992;26:850–854
  3. Cadera W, Silver MM, Burt L. Juvenile xanthogranuloma. Can J Ophthalmol. 1983;18:169–174
  4. Chang MW, Frieden IJ, Good W. The risk intraocular juvenile xanthogranuloma (survey of current practices and assessment of risk). J Am Acad Dermatol. 1996;34:445–449
  5. Cohen BA, Hood A. Xanthogranuloma (report on clinical and histologic findings in 64 patients). Pediatr Dermatol. 1989;6:262–266
  6. DeBarge LR, Chan CC, Greenberg SC, et al.  Chorioretinal, iris, and ciliary body infiltration by juvenile xanthogranuloma masquerading as uveitis. Surv Ophthalmol. 1994;39:65–71
  7. Enzinger FM, Weiss SW. Juvenile xanthogranuloma. In:  Enzinger FM,  Weiss SW editor. Soft Tissue Tumors. St Louis: Mosby; 1983;p. 135–140
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  10. Godde-Jolly D, Rozenbaum J, Chazalon T: [2 cases of juvenile xanthogranuloma. Diagnostic and therapeutic problems posed by the iridic localization of the disease]. Bull Soc Ophtalmol Fr 85:889–93, 1985
  11. Gonzalez-Crussi F, Campbell RJ. Juvenile xanthogranuloma (ultrastructural study). Arch Pathol. 1970;89:65–72
  12. Harley RD, Romayananda N, Chan GH. Juvenile xanthogranuloma. J Pediatr Ophthalmol Strabismus. 1982;19:33–39
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  14. Lever WF, Schaumberg-Lever G. In: Histopathology of the skin. Philadelphia: JB Lippincott; 1991;p. 442–443
  15. Marrogi AJ, Dehner LP, Coffin CM, Wick MR. Benign cutaneous histiocytic tumors in childhood and adolescence, excluding Langerhans cell proliferations. A clinicopathologic and immunohistochemical analysis. Am J Dermatopathol. 1992;14:8–18
  16. McMenamin PG, Crewe J, Morrison S, Holt PG. Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye. Invest Ophthalmol Vis Sci. 1994;35:3234–3250
  17. Muller RP, Junemann G: [Results of radiotherapy in case of juvenile xanthogranuloma of the iris]. Strahlentherapie 159:277–82, 1983
  18. Parmley VC, George DP, Fannin LA. Juvenile xanthogranuloma of the iris in an adult. Arch Ophthalmol. 1998;116:377–379
  19. Sanders TE. Intraocular juvenile xanthogranuloma (nevoxanthogranuloma) (a survey of 20 cases). Trans Am Ophthalmol Soc. 1960;58:59–74
  20. Schwartz LW, Rodrigues MM, Hallett JW. Juvenile xanthogranuloma diagnosed by paracentesis. Am J Ophthalmol. 1974;77:243–246
  21. Treacy KW, Letson RD, Summers CG. Subconjunctival steroid in the management of uveal juvenile xanthogranuloma (a case report). J Pediatr Ophthalmol Strabismus. 1990;27:126–128
  22. Wertz FD, Zimmerman LE, McKeown CA, et al.  Juvenile xanthogranuloma of the optic nerve, disc, retina, and choroid. Ophthalmology. 1982;89:1331–1335
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☆ Supported in part by National Institutes of Health core grant EY03040 and by an unrestricted grant from Research to Prevent Blindness, New York, New York.

PII: S0039-6257(01)00253-3

Survey of Ophthalmology
Volume 46, Issue 2 , Pages 164-171 , September 2001

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