Survey of Ophthalmology
Volume 47, Issue 1 , Pages 36-41, January 2002

Two Discrete Choroidal Melanomas in an Eye with Ocular Melanocytosis

  • Santosh G Honavar, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA USA
    • Ocular Oncology Service, LV Prasad Eye Institute, Hyderabad, India
    • ,
  • Carol L Shields, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA USA
    • Corresponding Author InformationReprint address: Carol L. Shields, MD, Oncology Service, Wills Eye Hospital, 900 Walnut Street, Philadelphia, PA, 19107
    • ,
  • Arun D Singh, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA USA
    • ,
  • Hakan Demirci, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA USA
    • ,
  • Bryan K Rutledge, MD

      Affiliations

    • Retina Vitreous Surgeons, Syracuse, NY, USA
    • ,
  • Jerry A Shields, MD

      Affiliations

    • Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA USA
    • ,
  • Ralph C Eagle Jr, MD

      Affiliations

    • Pathology Department, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA USA

MILTON BONIUK AND STEFAN SEREGARD, EDITORS

Abstract 

We report a case of multifocal choroidal melanoma arising in an eye with ocular melanocytosis and review the pertinent literature. A 63-year-old Caucasian male with ocular melanocytosis in the left eye was found to have two discrete choroidal melanomas in the same eye. Histopathology of the enucleated eye confirmed the diagnosis of two discrete choroidal melanomas of mixed cell type within a region of choroidal melanocytosis. It is estimated that 1 in 160,000 patients with unilateral ocular melanocytosis may develop two uveal melanomas, based on the reported data. On the basis of random chance, patients with two melanomas in the same eye would be expected to have approximately 1000-fold greater likelihood of underlying ocular melanocytosis than the general Caucasian population. In conclusion, multifocal choroidal melanoma is rare and may be related to underlying ocular melanocytosis.

Keywords:  choroid, melanocytosis, melanoma, tumor, uvea

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PII: S0039-6257(01)00281-8

Survey of Ophthalmology
Volume 47, Issue 1 , Pages 36-41, January 2002

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