Survey of Ophthalmology
Volume 47, Supplement 1 , Pages S97-S104, August 2002

Current Status of Prostaglandin Therapy:☆

Latanoprost and Unoprostone

  • Remo Susanna Jr, MD

      Affiliations

    • Corresponding Author InformationReprint address: Remo Susanna, Jr, MD, Associate Professor University of São Paulo, Glaucoma Service Director, Department of Ophthalmology, 05455-000 Av. São Gualter 99, São Paulo, Brazil
    • University of São Paulo, Department of Ophthalmology, São Paulo, Brazil
    • ,
  • Paul Chew, FRCSE

      Affiliations

    • National University of Singapore, Department of Ophthalmology, Singapore, Singapore
    • ,
  • Yoshiaki Kitazawa, MD

      Affiliations

    • Gifu University, Akasaka Kitazawa Eye Clinic, Tokyo, Japan

Abstract 

Latanoprost, a prostaglandin F2α analog prodrug, and unoprostone, an analog of a prostaglandin metabolite, have been shown to be effective in decreasing intraocular pressure when used alone or in combination with other ocular hypotensive agents. The increase in the uveoscleral outflow and some of the side effects are probably FP-receptor mediated, which may account for some differences between the cited drugs. This article reviews the recent literature available on the clinical efficacy of these prostanoids, as well as the studies directly comparing these drugs.

Keywords:  intraocular pressure, glaucoma, prostaglandin analog, uveoscleral outflow

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☆ The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article.

PII: S0039-6257(02)00308-9

Survey of Ophthalmology
Volume 47, Supplement 1 , Pages S97-S104, August 2002

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