Survey of Ophthalmology
Volume 47, Issue 4 , Pages 368-374 , July 2002

Malignant Ectomesenchymoma of the Orbit in a Child: Case Report and Review of the Literature

  • Peter Paikos, MD

      Affiliations

    • Departments of Ophthalmology, Agia Sofia Children's Hospital, Athens, Greece
    • Corresponding Author InformationReprint address: Peter Paikos, MD, AGIA SOFIA Children's Hospital, Dept. of Ophthalmology, Thivon and Livadias str., Goudi, 11527, Athens, Greece
  • ,
  • Miltiadis Papathanassiou, MD

      Affiliations

    • Departments of Ophthalmology, Agia Sofia Children's Hospital, Athens, Greece
  • ,
  • Kalliopi Stefanaki, MD

      Affiliations

    • Departments of Pathology, Agia Sofia Children's Hospital, Athens, Greece
  • ,
  • Maria Fotopoulou, MD

      Affiliations

    • Departments of Ophthalmology, Agia Sofia Children's Hospital, Athens, Greece
  • ,
  • Spyropoulos Grigorios, MD

      Affiliations

    • Departments of Ophthalmology, Agia Sofia Children's Hospital, Athens, Greece
  • ,
  • Foteini Tzortzatou, MD

      Affiliations

    • Departments of Oncology, Agia Sofia Children's Hospital, Athens, Greece

References 

  1. Ambros IM, Ambros PF, Strehl S. MIC2 is a specific marker for Ewings sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewings sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer. 1991;67:1886–1893
  2. Bechtold RE, Sumner TE: Case of the month: ectomesenchymoma (malignant testicular tumor). J Ultrasound Med 3:R20, R22, 1984
  3. Bittinger A, Rossberg C, Rodehuser M. Primary malignant ectomesenchymoma of the orbit. Gen Diagn Pathol. 1997;142:221–225
  4. Bolande RP. Neurocristopathy (its growth and development in 20 years). Pediatr Pathol Lab Med. 1997;17:1–25
  5. Boue DR, Parham DM, Webber B. Clinicopathologic study of ectomesenchymomas from Intergroup Rhabdomyosarcoma Study Groups III and IV. Pediatr Dev Pathol. 2000;3:290–300
  6. Bronner-Fraser M. Neural crest cell formation and migration in the developing embryo. FASEB J. 1994;8:699–706
  7. Bullock JD, Goldberg SH, Rakes SM, et al.  Primary orbital neuroblastoma. Arch Ophthalmol. 1989;107:1031–1033
  8. Caillaud JM, Gerard-Marchant R, Marsden HB. Histopathological classification of childhood rhabdomyosarcoma (a report from the International Society of Pediatric Oncology pathology panel). Med Pediatr Oncol. 1989;17:391–400
  9. Cozzutto C, Comelli A, Bandelloni R. Ectomesenchymoma. Report of two cases. Virchows Arch A Pathol Anat Histopathol. 1982;398:185–195
  10. Couly G, Grapin-Botton A, Coltey P, Le Douarin NM. The regeneration of the cephalic neural crest, a problem revisited (the regenerating cells originate from the contralateral or from the anterior and posterior neural fold). Development. 1996;122:3393–3407
  11. Dalley RW. Fibrous histiocytoma and fibrous tissue tumors of the orbit. Radiol Clin North Am. 1999;37:185–194
  12. de Alava E, Lozano MD, Sola I, et al.  Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation. Hum Pathol. 1998;29:181–184
  13. Dias P, Parham DM, Shapiro DN, et al.  Monoclonal antibodies to the myogenic regulatory protein MyoD1 (epitope mapping and diagnostic utility). Cancer Res. 1992;52:6431–6439
  14. Dutton JJ, Rose JG, DeBacker CM, Gayre G. Orbital Ewings sarcoma of the orbit. Ophthal Plast Reconstr Surg. 2000;16:292–300
  15. Edwards V, Tse G, Doucet J, et al.  Rhabdomyosarcoma metastasizing as a malignant ectomesenchymoma. Ultrastruct Pathol. 1999;23:267–273
  16. Freitas AB, Aguiar PH, Miura FK, et al.  Malignant ectomesenchymoma. Case report and review of the literature. Pediatr Neurosurg. 1999;30:320–330
  17. Garin-Chesa P, Fellinger EJ, Huvos AG, et al.  Immunohistochemical analysis of neural cell adhesion molecules. Differential expression in small round cell tumors of childhood and adolescence. Am J Pathol. 1991;139:275–286
  18. Goldsby RE, Bruggers CS, Brothman AR. Spindle cell sarcoma of the kidney with ganglionic elements (malignant ectomesenchymoma) associated with chromosomal abnormalities and a review of the literature. J Pediatr Hematol Oncol. 1998;20:160–164
  19. Govender D, Hadley GP. Ectomesenchymoma of the prostate (histological diagnostic criteria). Pediatr Surg Int. 1999;15:68–70
  20. Grosfeld JL. Risk-based management (current concepts of treating malignant solid tumors of childhood). J Am Coll Surg. 1999;189:407–425
  21. Hajivassiliou CA, Carachi R, Simpson E, et al.  Ectomesenchymoma (one or two tumors? Case report and review of the literature). J Pediatr Surg. 1997;32:1351–1355
  22. Hibshoosh H, Lattes R. Immunohistochemical and molecular genetic approaches to soft tissue tumor diagnosis (a primer). Semin Oncol. 1997;24:515–525
  23. Johnston MC, Noden DM, Hazelton RD. Origins of avian ocular and periocular tissues. Exp Eye Res. 1979;29:27–43
  24. Karcioglu Z, Someren A, Mathes SJ. Ectomesenchymoma. A malignant tumor of migratory neural crest (ectomesenchyme) remnants showing ganglionic, schwannian, melanocytic and rhabdomyoblastic differentiation. Cancer. 1977;39:2486–2496
  25. Kasantikul V, Shuangshoti S, Cutchavaree A, Bunyaphiphat P. Parapharyngeal malignant ectomesenchymoma (combined malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation). J Laryngol Otol. 1987;101:508–515
  26. Kawamoto EH, Weidner N, Agostini RM, Jaffe R. Malignant ectomesenchymoma of soft tissue. Report of two cases and review of the literature. Cancer. 1987;59:1791–1802
  27. Kiratli H, Bilgic S, Gedikoglu G, et al.  Primitive neuroectodermal tumor of the orbit in an adult. A case report and literature review. Ophthalmology. 1999;106:98–102
  28. Kivela T, Tarkkanen A. Orbital germ cell tumors revisited (a clinicopathological approach to classification). Surv Ophthalmol. 1994;38:541–554
  29. Kodet R, Newton WA, Hamoudi AB. Orbital rhabdomyosarcomas and related tumors in childhood (relationship of morphology to prognosis—an Intergroup Rhabdomyosarcoma study). Med Pediatr Oncol. 1997;29:51–60
  30. Koeller KK: Mesenchymal chondrosarcoma and simulating lesions of the orbit. Radiol Clin North Am 37:203–17, xii, 1999
  31. Le Douarin NM, Dupin E, Ziller C. Genetic and epigenetic control in neural crest development. Curr Opin Genet Dev. 1994;4:685–695
  32. Matsko TH, Schmidt RA, Milam AH, Orcutt JC. Primary malignant ectomesenchymoma of the orbit. Br J Ophthalmol. 1992;76:438–441
  33. Medina LS, Barnes PD, Donovan MJ, Taylor GA: Radiologic-Pathologic Conference of Childrens Hospital Boston: intraconal mass in the orbit of an infant. Pediatr Radiol 27:682–4, 1997
  34. Mouton SC, Rosenberg HS, Cohen MC, et al.  Malignant ectomesenchymoma in childhood. Pediatr Pathol Lab Med. 1996;16:607–624
  35. Newton WA, Gehan EA, Webber BL. Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification—an Intergroup Rhabdomyosarcoma Study. Cancer. 1995;76:1073–1085
  36. Noden DM. In: Periocular mesenchyme (neural crest and mesodermal interactions, in Jaxobiec FA: Ocular anatomy, embryology and teratology). Philadelphia: Harper and Row; 1986;p. 2461–2476
  37. Pellin A, Boix J, Blesa JR, et al.  EWS/FLI-1 rearrangement in small round cell sarcomas of bone and soft tissue detected by reverse transcriptase polymerase chain reaction amplification. Eur J Cancer. 1994;30A:827–831
  38. Qualman SJ, Coffin CM, Newton WA. Intergroup Rhabdomyosarcoma Study (update for pathologists). Pediatr Dev Pathol. 1998;1:550–561
  39. Rootman J. Frequency and differential diagnosis of orbital disease. In:  Rootman J editors. Disease of the Orbit (a Multidisciplinary Approach). Philadelphia: Lippincot; 1988;p. 119–139
  40. Shuangshoti S, Kasantikul V, Suwangool P, Chittmittrapap S. Malignant neoplasm of mixed mesenchymal and neuroepithelial origin (ectomesenchymoma) of thigh. J Surg Oncol. 1984;27:208–213
  41. Singh AD, Husson M, Shields CL, et al.  Primitive neuroectodermal tumor of the orbit. Arch Ophthalmol. 1994;112:217–221
  42. Sirikulchayanonta V, Wongwaisayawan S. Malignant ectomesenchymoma (neoplasm of mixed mesenchymal and neuroepithelial origin) of wrist joint. J Med Assoc Thai. 1984;67:356–361
  43. Tsokos M. Peripheral primitive neuroectodermal tumors. Diagnosis, classification, and prognosis. Perspect Pediatr Pathol. 1992;16:27–98
  44. Valles San Leandro L, Arcas Martinez-Salas I, Villegas Perez MP, et al.  Esthesioneuroblastoma (an atypical form of manifestation). Eur J Ophthalmol. 1994;4:118–122
  45. Woyke S, Gorczyca W, Juszkiewicz P: [Malignant ectomesenchymoma]. Patol Pol 38:117–20, 1987

PII: S0039-6257(02)00313-2

Survey of Ophthalmology
Volume 47, Issue 4 , Pages 368-374 , July 2002