Survey of Ophthalmology
Volume 47, Issue 5 , Pages 470-490 , September 2002

Ocular Adnexal Lymphomas: Five Case Presentations and a Review of the Literature

References 

  1. A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med. 1993;329:987–994
  2. Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia/lymphoma (a report of the second nationwide study of Japan). The T- and B-Cell Malignancy Study Group. Jpn J Clin Oncol. 1985;15:517–535
  3. Auw-Haedrich C, Coupland SE, Kapp A, et al.  Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Revised European and American Lymphoma. Br J Ophthalmol. 2001;85:63–69
  4. Baldini L, Blini M, Guffanti A, et al.  Treatment and prognosis in a series of primary extranodal lymphomas of the ocular adnexa. Ann Oncol. 1998;9:779–781
  5. Bessell EM, Henk JM, Wright JE, Whitelocke RA. Orbital and conjunctival lymphoma treatment and prognosis. Radiother Oncol. 1988;13:237–244
  6. Brooks HL, Downing J, McClure JA, Engel HM. Orbital Burkitt's lymphoma in a homosexual man with acquired immune deficiency. Arch Ophthalmol. 1984;102:1533–1537
  7. Carbone PP, Kaplan HS, Musshoff K, et al.  Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res. 1971;31:1860–1861
  8. Cordell JL, Falini B, Erber WN, et al.  Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984;32:219–229
  9. Coupland SE, Foss HD, Hidayat AA, et al.  Extranodal marginal zone B-cell lymphomas of the uvea (an analysis of 13 cases). J Pathol. 2002;197:333–340
  10. Coupland SE, Foss HD, Anagnostopoulos I, et al.  Immunoglobulin VH gene expression among extranodal marginal zone B-cell lymphomas of the ocular adnexa. Invest Ophthalmol Vis Sci. 1999;40:555–562
  11. Coupland SE, Foss HD, Assaf C, et al.  T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues (a clinicopathologic, immunohistochemical, and molecular study of seven cases). Ophthalmology. 1999;106:2109–2120
  12. Coupland SE, Krause L, Delecluse HJ, et al.  Lymphoproliferative lesions of the ocular adnexa. Analysis of. 1998;112(cases. Ophthalmology 105):1430–1441
  13. Coupland SE, Wiegel T, Auw-Haedrich C, et al: Lymphoproliferative Läsionen der okulären Adnexe und intraokuläre Lymphome. Der Onkologe 5:792ä804, 1999
  14. Edelstein C, Shields JA, Shields CL, et al.  Non-African Burkitt lymphoma presenting with oral thrush and an orbital mass in a child. Am J Ophthalmol. 1997;124:859–861
  15. Ellis JH, Banks PM, Campbell RJ, Liesegang TJ. Lymphoid tumors of the ocular adnexa. Clinical correlation with the working formulation classification and immunoperoxidase staining of paraffin sections. Ophthalmology. 1985;92:1311–1324
  16. Esik O, Ikeda H, Mukai K, Kaneko A. A retrospective analysis of different modalities for treatment of primary orbital non-Hodgkin's lymphomas. Radiother Oncol. 1996;38:13–18
  17. Flanders AE, Espinosa GA, Markiewicz DA, Howell DD. Orbital lymphoma. Role of CT and MRI. Radiol Clin North Am. 1987;25:601–613
  18. Fratkin JD, Shammas HF, Miller SD. Disseminated Hodgkin's disease with bilateral orbital involvement. Arch Ophthalmol. 1978;96:102–104
  19. Hardman Lea S, Kerr Muir M, Wotherspoon AC, et al.  Mucosal-associated lymphoid tissue lymphoma of the conjunctiva. Arch Ophthalmol. 1994;112:1207–1212
  20. Harris NL. Extranodal lymphoid infiltrates and mucosa-associated lymphoid tissue (MALT) (a unifying concept). Am J Surg Pathol. 1991;15:879–884
  21. Harris NL. Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue and monocytoid B-cell lymphoma. Related entities that are distinct from other low-grade B-cell lymphomas. Arch Pathol Lab Med. 1993;117:771–775
  22. Harris NL, Jaffe ES, Stein H, et al.  A revised European-American classification of lymphoid neoplasms (a proposal from the International Lymphoma Study Group). Blood. 1994;84:1361–1392 [see comments]
  23. Hempel M, Hinkelbein W. Eye sequelae following external irradiation. Recent Results Cancer Res. 1993;130:231–236
  24. Henderson JW, Banks PM, Yeatts RP. T-cell lymphoma of the orbit. Mayo Clin Proc. 1989;64:940–944
  25. Hornblass A, Jakobiec FA, Reifler DM, Mines J. Orbital lymphoid tumors located predominantly within extraocular muscles. Ophthalmology. 1987;94:688–697
  26. Inagaki H, Okabe M, Seto M, et al.  API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma (multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens). Am J Pathol. 2001;158:699–706
  27. Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue (a distinctive type of B-cell lymphoma). Cancer. 1983;52:1410–1416
  28. Isaacson PG. Mucosa-associated lymphoid tissue lymphoma. Semin Hematol. 1999;36:139–147
  29. Isaacson PG, Norton AJ. Extranodal Lymphomas. Edinburgh: Churchill Livingstone; 1994;
  30. Jaffe ES, Harris NL, Stein H, Vardiman JW: World Health Organization Classification of Tumours. Tumours of Haematopoietic and Lymphoid Tissues. Pathology and Genetics. Lyon: IARC Press, 2001
  31. Jakobiec FA. Orbital Hodgkin's disease (clinicopathologic conference). N Eng J Med. 1989;320:447–457
  32. Jakobiec FA, Knowles DM. An overview of ocular adnexal lymphoid tumors. Trans Am Ophthalmol Soc. 1989;87:420–442 discussion 442–4
  33. Jakobiec FA, Lefkowitch J, Knowles DM. B- and T-lymphocytes in ocular disease. Ophthalmology. 1984;91:635–654
  34. Jakobiec FA, Neri A, Knowles DM. Genotypic monoclonality in immunophenotypically polyclonal orbital lymphoid tumors. A model of tumor progression in the lymphoid system. The 1986 Wendell Hughes lecture. Ophthalmology. 1987;94:980–994
  35. Jenkins C, Rose GE, Bunce C, et al.  Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival. Br J Ophthalmol. 2000;84:907–913
  36. Jereb B, Lee H, Jakobiec FA, Kutcher J. Radiation therapy of conjunctival and orbital lymphoid tumors. Int J Radiat Oncol Biol Phys. 1984;10:1013–1019
  37. Johnson TE, Tse DT, Byrne GE, et al.  Ocular-adnexal lymphoid tumors (a clinicopathologic and molecular genetic study of 77 patients). Ophthal Plast Reconstr Surg. 1999;15:171–179
  38. Keleti D, Flickinger JC, Hobson SR, Mittal BB. Radiotherapy of lymphoproliferative diseases of the orbit. Surveillance of. 1992;65(cases. Am J Clin Oncol 15):422–427
  39. Kennerdell JS, Flores NE, Hartsock RJ. Low-dose radiotherapy for lymphoid lesions of the orbit and ocular adnexa. Ophthal Plast Reconstr Surg. 1999;15:129–133
  40. Kirsch LS, Brownstein S, Codere F. Immunoblastic T-cell lymphoma presenting as an eyelid tumor. Ophthalmology. 1990;97:1352–1357
  41. Knieper P. Lymphoblastic lymphoma of the orbit. Orbit. 1982;1:235–240
  42. Knowles DM. The extranodal lymphoid infiltrate (a diagnostic dilemma). Semin Diagn Pathol. 1985;2:147–151
  43. Knowles DM, Chamulak G, Subar M, et al.  Clinicopathologic, immunophenotypic, and molecular genetic analysis of AIDS-associated lymphoid neoplasia. Clinical and biologic implications. Pathol Annu. 1988;23(Pt 2):33–67
  44. Knowles DM, Jakobiec FA, McNally L, Burke JS. Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids) (a prospective multiparametric analysis of 108 cases during 1977 to 1987). Hum Pathol. 1990;21:959–973
  45. Kuppers R, Rajewsky K, Hansmann ML. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol. 1997;27:1398–1405
  46. Laroche L, Laroche L, Pavlakis E, Saraux H. Immunological characterization of an ocular adnexal lymphoid T tumor by monoclonal antibodies. Ophthalmologica. 1983;187:43–49
  47. Leidenix MJ, Mamalis N, Olson RJ, et al.  Primary T-cell immunoblastic lymphoma of the orbit in a pediatric patient. Ophthalmology. 1993;100:998–1002
  48. Letschert JG, Gonzalez D, Oskam J, et al.  Results of radiotherapy in patients with stage I orbital non-Hodgkin's lymphoma. Radiother Oncol. 1991;22:36–44
  49. Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A, et al.  Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet. 2001;357:39–40
  50. Magrath IT, Janus C, Edwards BK, et al.  An effective therapy for both undifferentiated (including Burkitt's) lymphomas and lymphoblastic lymphomas in children and young adults. Blood. 1984;63:1102–1111
  51. Mannami T, Yoshino T, Oshima K, et al.  Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders (characterization of malt lymphoma and reactive lymphoid hyperplasia). Mod Pathol. 2001;14:641–649
  52. McNally L, Jakobiec FA, Knowles DMD. Clinical, morphologic, immunophenotypic, and molecular genetic analysis of bilateral ocular adnexal lymphoid neoplasms in 17 patients. Am J Ophthalmol. 1987;103:555–568
  53. Medeiros LJ, Harmon DC, Linggood RM, Harris NL. Immunohistologic features predict clinical behavior of orbital and conjunctival lymphoid infiltrates. Blood. 1989;74:2121–2129
  54. Medeiros LJ, Harris NL. Immunohistologic analysis of small lymphocytic infiltrates of the orbit and conjunctiva. Hum Pathol. 1990;21:1126–1131
  55. Medeiros LJ, Harris NL. Lymphoid infiltrates of the orbit and conjunctiva. A morphologic and immunophenotypic study of. 1989;99(cases. Am J Surg Pathol 13):459–471
  56. Meekins B, Proia AD, Klintworth GK. Cutaneous T-cell lymphoma presenting as a rapidly enlarging ocular adnexal tumor. Ophthalmology. 1985;92:1288–1293
  57. Minehan KJ, Martenson JA, Garrity JA, et al.  Local control and complications after radiation therapy for primary orbital lymphoma (a case for low-dose treatment). Int J Radiat Oncol Biol Phys. 1991;20:791–796
  58. Morgan G: Lymphocytic tumors of the orbit. Modern Problems in Ophthalmology, Vol 14. Basel: Karger, 1975, pp 35–8
  59. Motegi M, Yonezumi M, Suzuki H, et al.  API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products. Am J Pathol. 2000;156:807–812
  60. Murphy SB, Hustu HO. A randomized trial of combined modality therapy of childhood non-Hodgkin's lymphoma. Cancer. 1980;45:630–637
  61. Nakata M, Matsuno Y, Katsumata N, et al.  Histology according to the Revised European-American Lymphoma Classification significantly predicts the prognosis of ocular adnexal lymphoma. Leuk Lymphoma. 1999;32:533–543
  62. Neri A, Jakobiec FA, Pelicci PG, et al.  Immunoglobulin and T cell receptor beta chain gene rearrangement analysis of ocular adnexal lymphoid neoplasms (clinical and biologic implications). Blood. 1987;70:1519–1529
  63. Norton AJ, Jordan S, Yeomans P. Brief, high-temperature heat denaturation (pressure cooking) (a simple and effective method of antigen retrieval for routinely processed tissues). J Pathol. 1994;173:371–379
  64. Okuda K, Matsuo N, Matsuo H, Nakano K: [A case of orbital lymphoma (Hodgkin's paragranuloma)]. Nippon Ganka Kiyo 18:504–10, 1967
  65. Pangalis GA, Nathwani BN, Rappaport H. Malignant lymphoma, well differentiated lymphocytic (its relationship with chronic lymphocytic leukemia and macroglobulinemia of Waldenstrom). Cancer. 1977;39:999–1010
  66. Park KL, Goins KM. Hodgkin's lymphoma of the orbit associated with acquired immunodeficiency syndrome. Am J Ophthalmol. 1993;116:111–112 [letter]
  67. Patel S, Rootman J. Nodular sclerosing Hodgkin's disease of the orbit. Ophthalmology. 1983;90:1433–1436
  68. Polito E, Leccisotti A, Galieni P. Clinical and radiological presentation of 95 orbital lymphoid tumors. Graefe Arch Clin Exp Ophthalmol. 1996;234:504–509
  69. Project N-HsLPC. National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas (summary and description of a working formulation for clinical usage). Cancer. 1982;49:2112–2135
  70. Reifler DM, Warzynski MJ, Blount WR, et al.  Orbital lymphoma associated with acquired immune deficiency syndrome (AIDS). Surv Ophthalmol. 1994;38:371–380
  71. Salhany KE, Pietra GG. Extranodal lymphoid disorders. Am J Clin Pathol. 1993;99:472–485
  72. Saltzstein S. Extranodal malignant lymphomas and pseudolymphomas. Path Ann. 1969;4:159–184
  73. Sasai K, Yamabe H, Dodo Y, et al.  Non-Hodgkin's lymphoma of the ocular adnexa. Acta Oncol. 2001;40:485–490
  74. Sherman MD, Van Dalen JT, Conrad K. Bilateral orbital infiltration as the initial sign of a peripheral T-cell lymphoma presenting in a leukemic phase. Ann Ophthalmol. 1990;22:93–95
  75. Shields CL, Shields JA, Carvalho C, et al.  Conjunctival lymphoid tumors (clinical analysis of 117 cases and relationship to systemic lymphoma). Ophthalmology. 2001;108:979–984
  76. Shih LY, Liang DC. Non-Hodgkin's lymphomas in Asia. Hematol Oncol Clin North Am. 1991;5:983–1001
  77. Sigelman J, Jakobiec FA. Lymphoid lesions of the conjunctiva (relation of histopathology to clinical outcome). Ophthalmology. 1978;85:818–843
  78. Smitt MC, Donaldson SS. Radiotherapy is successful treatment for orbital lymphoma. Int J Radiat Oncol Biol Phys. 1993;26:59–66
  79. Tomlinson IM, Cook GP, Walter G, et al.  A complete map of the human immunoglobulin VH locus. Ann NY Acad Sci. 1995;764:43–46
  80. Wegner A, Schmidt T, Fellbaum C: [Primary manifestation of Burkitt's lymphoma of the non-African type in the orbits]. Klin Monatsbl Augenheilkd 203:128–31, 1993
  81. Weisenthal RW, Streeten BW, Dubansky AS, et al.  Burkitt lymphoma presenting as a conjunctival mass. Ophthalmology. 1995;102:129–134
  82. White WA, Ferry JA, Harris NL, Grove AS. Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type. Ophthalmology. 1995;102:1994–2006
  83. Wotherspoon AC, Diss TC, Pan LX, et al.  Primary low-grade B-cell lymphoma of the conjunctiva (a mucosa-associated lymphoid tissue type lymphoma). Histopathology. 1993;23:417–424
  84. Wotherspoon AC, Doglioni C, Diss TC, et al.  Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575–577
  85. Wotherspoon AC, Ortiz Hidalgo C, Falzon MR, Isaacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991;338:1175–1176
  86. Wu Hy Kaartinen M. The somatic hypermutation activity of a follicular lymphoma links to large insertions and deletions of immunoglobulin genes. Scand J Immunol. 1995;42:52–59
  87. Yeo JH, Jakobiec FA, Abbott GF, Trokel SL. Combined clinical and computed tomographic diagnosis of orbital lymphoid tumors. Am J Ophthalmol. 1982;94:235–245

PII: S0039-6257(02)00337-5

Survey of Ophthalmology
Volume 47, Issue 5 , Pages 470-490 , September 2002

Article Tools

* Image Usage & Resolution