Survey of Ophthalmology
Volume 49, Issue 1 , Pages 51-77 , January 2004

The amniotic membrane in ophthalmology

  • Harminder S Dua, MD, FRCS, PhD

      Affiliations

    • Corresponding Author InformationReprint address: Harminder S. Dua, Division of Ophthalmology and Visual Sciences, B floor, Eye Ear Nose Throat Centre, University Hospital, Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom.
  • ,
  • Jose A.P Gomes, MD, PhD

      Affiliations

  • ,
  • Anthony J King, MD, FRCS

      Affiliations

  • ,
  • V.Senthil Maharajan, MS, FRCS

      Affiliations

References 

  1. Adds PJ, Hunt C, Hartley S. Bacterial contamination of amniotic membrane. Br J Ophthalmol. 2001;85:228–230
  2. Adinolfi M, Akle CA, McColl I. Expression of HLA antigens, beta 2-microglobulin and enzymes by human amniotic epithelial cells. Nature. 1982;295:325–327
  3. Akle CA, Adinolfi M, Welsh KI. Immunogenicity of human amniotic epithelial cells after transplantation into volunteers. Lancet. 1981;2:1003–1005
  4. Anderson DF, Ellies P, Pires RT, Tseng SC. Amniotic membrane transplantation for partial limbal stem cell deficiency. Br J Ophthalmol. 2001;85:567–575
  5. Anderson DF, Prabhasawat P, Alfonso E, Tseng SC. Amniotic membrane transplantation after the primary surgical management of band keratopathy. Cornea. 2001;20:354–361
  6. Aplin JD, Campbell S, Allen TD. The extracellular matrix of human amniotic epithelium: ultrastructure, composition and deposition. J Cell Sci. 1985;79:119–136
  7. Arora M, Jaroudi KA, Hamilton CJ, Dayel F. Controlled comparison of interceed and amniotic membrane graft in the prevention of postoperative adhesions in the rabbit uterine horn model. Eur J Obstet Gynecol Reprod Biol. 1994;55:179–182
  8. Avila M, Espana M, Moreno C, Pena C. Reconstruction of ocular surface with heterologous limbal epithelium and amniotic membrane in a rabbit model. Cornea. 2001;20:414–420
  9. Azuara-Blanco A, Pillai CT, Dua HS. Amniotic membrane transplantation for ocular surface reconstruction. Br J Ophthalmol. 1999;83:399–402
  10. Barton K, Budenz DL, Khaw PT, Tseng SC. Glaucoma filtration surgery using amniotic membrane transplantation. Invest Ophthalmol Vis Sci. 2001;42:1762–1768
  11. Batmanov IE, Egorova KS, Kolesnikova LN. Use of fresh amnion in the treatment of corneal diseases. Vestn Oftalmol. 1990;106:17–19
  12. Beham A, Denk H, Desoye G. The distribution of intermediate filament proteins, actin and desmoplakins in human placental tissue as revealed by polyclonal and monoclonal antibodies. Placenta. 1988;9:479–482
  13. Benedetti WL, Sala MA, Alvarez H. Histochemical demonstration of enzymes in the umbilical cord and membranes of human term pregnancy. Eur J Obstet Gynecol Reprod Biol. 1973;3:185–189
  14. Benedetto MT, De Cicco F, Rossiello F. Oxytocin receptor in human fetal membranes at term and during labor. J Steroid Biochem. 1990;35:205–208
  15. Bennett JP, Matthews R, Faulk WP. Treatment of chronic ulceration of the legs with human amnion. Lancet. 1980;1:1153–1156
  16. Bose B. Burn wound dressing with human amniotic membrane. Ann R Coll Surg Engl. 1979;61:444–447
  17. Boudreau N, Sympson CJ, Werb Z, Bissell MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science. 1995;267:891–893
  18. Boudreau N, Werb Z, Bissell MJ. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc Natl Acad Sci USA. 1996;93:3509–3513
  19. Bourne GL. The microscopic anatomy of the human amnion and chorion. Am J Obstet Gynecol. 1960;79:1070–1073
  20. Budenz DL, Barton K, Tseng SC. Amniotic membrane transplantation for repair of leaking glaucoma filtering blebs. Am J Ophthalmol. 2000;130:580–588
  21. Burger K. Artificial vaginal reconstruction with the help of amnios. Zentralblatt Fur Gynakol. 1937;2437–2440
  22. Burgos H, Sergeant RJ. Lyophilized human amniotic membranes used in reconstruction of the ear. [letter] J R Soc Med. 1983;76:433
  23. Cameron P, Pagnon J, Reece J, et al: Inactivation of intracellular and extracellular HIV-1 after glycerol treatment at 4°C. Workshop on glycerol-preserved donor skin. Amsterdam, 3 October 1996. Quoted by Maral et al 1999
  24. Casey ML, Word RA, MacDonald PC. Endothelin-1 gene expression and regulation of endothelin mRNA and protein biosynthesis in avascular human amnion. Potential source of amniotic fluid endothelin. J Biol Chem. 1991;266:5762–5768
  25. Champliaud MF, Lunstrum GP, Rouselle P. Human amnionn contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment. J Cell Biol. 1996;132:1189–1198
  26. Chen HJ, Pires RT, Tseng SC. Amniotic membrane transplantation for severe neurotrophic corneal ulcers. Br J Ophthalmol. 2000;84:826–833
  27. Cheung PY, Walton JC, Tai HH. Immunocytochemical distribution and localization of 15-hydroxyprostaglandin dehydrogenase in human fetal membranes, decidua, and placenta. Am J Obstet Gynecol. 1990;163:1445–1449
  28. Cho BJ, Djalilian AR, Obritsch WF. Conjunctival epithelial cells cultured on human amniotic membrane fail to transdifferentiate into corneal epithelial-type cells. Cornea. 1999;18:216–224
  29. Choi YS, Kim JY, Wee WR, Lee JH. Effect of the application of human amniotic membrane on rabbit corneal wound healing after excimer laser photorefractive keratectomy. Cornea. 1998;17:389–395
  30. Choi TH, Tseng SC. In vivo and in vitro demonstration of epithelial cell-induced myofibroblast differentiation of keratocytes and an inhibitory effect by amniotic membrane. Cornea. 2001;20:197–204
  31. Cleutjens JP, Havenith MG, Vallinga M. Monoclonal antibodies to native basement membranes reveal heterogeneous immunoreactivity patterns. Histochemistry. 1989;92:407–412
  32. Colocho G, Graham WP, Greene AE. Human amniotic membrane as a physiologic wound dressing. Arch Surg. 1974;109:370–373
  33. Crescimanno C, Muhlhauser J, Castellucci M. Immunocytochemical patterns of carbonic anhydrase isoenzymes in human placenta, cord and membranes. Placenta. 1993;14:A11
  34. Danforth DN, Hull RW. The microscopic anatomy of the fetal membranes with particular reference to the detailed structure of the amnion. Am J Obstet Gynecol. 1958;75:536–550
  35. Davis JW. Skin transplantation with a review of 550 cases at the Johns Hopkins Hospital. Johns Hopkins Med J. 1910;15:307
  36. de Rotth A. Plastic repair of conjunctival defects with fetal mebranes. Arch Ophthalmol. 1940;23:522–525
  37. Dhall K. Amnion graft for treatment of congenital absence of the vagina. Br J Obstet Gynecol. 1984;91:279–282
  38. Dua HS. The conjunctiva in corneal epithelial wound healing. Br J Ophthalmol. 1998;82:1407–1411
  39. Dua HS, Azuara-Blanco A. Limbal stem cells of the corneal epithelium. Surv Ophthalmol. 2000;44:415–425
  40. Dua HS, Azuara-Blanco A. Discussion on Amniotic membrane transplantation for acute chemical or thermal burns. Ophthalmology. 2000;107:990
  41. Dua HS, Azuara-Blanco . Amniotic membrane transplantation. Br J Ophthalmol. 1999;83:748–752
  42. Dua HS, Gomes JAP, Singh A. Corneal epithelial wound healing. Br J Ophthalmol. 1994;78:401–408
  43. Dua HS, King AJ, Joseph A. A new classification of ocular surface burns. Br J Ophthalmol. 2001;85:1379–1383
  44. Duchesne B, Tahi H, Galand A. Use of human fibrin glue and amniotic membrane transplant in corneal perforation. Cornea. 2001;20:230–232
  45. Faulk WP, Matthews R, Stevens PJ. Human amnion as an adjunct in wound healing. Lancet. 1980;1:1156–1158
  46. Franck O, Descargues G, Menguy E. Technique of harvesting and preparation of amniotic membranes. J Fr Ophtalmol. 2000;23:729–734
  47. Franco GR, de Carvalho AF, Kroon EG. Biological activities of a human amnioitic membrane interferon. Placenta. 1999;20:189–196
  48. Fujisato T, Tomihata K, Tabata Y. Cross-linking of amniotic membranes. J Biomater Sci Polym Ed. 1999;10:1171–1181
  49. Fujishima H, Shimazaki J, Shinozaki N, Tsubota K. Trabeculectomy with the use of amniotic membrane for uncontrollable glaucoma. Ophthalmic Surg Lasers. 1998;29:428–433
  50. Fukuda K, Chikama T, Nakamura M, Nishida T. Differential distribution of subchains of the basement membrane components type IV collagen and laminin among the amniotic membrane, cornea, and conjunctiva. Cornea. 1999;18:73–79
  51. Gabler B, Lohmann CP. Hypopyon after repeated transplantation of human amniotic membrane onto the corneal surface. Ophthalmology. 2000;107:1344–1346
  52. Gabric N, Maravicic I, Dekaris I. Human amniotic membrane in the reconstruction of the ocular surface. Doc Ophthalmol. 1999;98:273–283
  53. Galask RP, Snyder IS. Antimicrobial factors in amniotic fluid. Am J Obstet Gynecol. 1970;106:59–65
  54. Ganatra MA, Durrani KM. Method of obtaining and preparation of fresh human amniotic membrane for clinical use. J Pak Med Assoc. 1996;46:126–128
  55. Georgy MS, Aziz NL. Vaginoplasty using amnion graft: new surgical technique using the laparoscopic transillumination light. J Obstet Gynaecol. 1996;16:262–264
  56. Gharib M, Ure BM, Klose M. Use of amniotic grafts in the repair of gastroschisis. Pediatr Surg Int. 1996;11:96–99
  57. Gibb W, Lavoie JC. Effects of glucocorticoids on prostaglandin formation by human amnion. Can J Physiol Pharmacol. 1990;68:671–676
  58. Gilstrap LC, Cunningham FG. The bacterial pathogenesis of infection following cesarean section. Obstet Gynecol. 1979;53:545–549
  59. Gomes JAP, Komagome CM, Santos N. Membrana amniótica nas cirurgias reconstrutivas da superfı́cie ocular nas ceratoconjuntivites cicatriciais. Arq Bras Oftalmol. 1999;62:562–576
  60. Gossrau R, Graf R, Ruhnke M, Hanski C. Proteases in the human full-term placenta. Histochemistry. 1987;86:405–413
  61. Gris O, Guell JL, Lopez-Navidad A. Application of the amniotic membrane in ocular surface pathology. Ann Transplant. 1999;4:82–84
  62. Gruss JS, Jirsch DW. Human amniotic membrane: a versatile wound dressing. Can Med Assoc J. 1978;118:1237–1246
  63. Gudson J. A Bactericidin for bacillus subtilis in pregnancy. J Immunol. 1962;88:494–499
  64. Guo M, Grinnell F. Basement membrane and human epidermal differentiation in vitro. J Invest Dermatol. 1989;93:372–378
  65. Haberal M, Oner Z, Bayraktar U, Bilgin N. The use of silver nitrate-incorporated amniotic membrane as a temporary dressing. Burns. 1987;13:159–163
  66. Hanada K, Shimazaki J, Shimmura S, Tsubota K. Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera. Am J Ophthalmol. 2001;131:324–331
  67. Hao Y, Ma DH, Hwang DG. Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane. Cornea. 2000;19:348–352
  68. Hay JC, Persaud TVN. Normal embryonic and fetal development. In:  Reece EA,  Hobbins JC editor. Medicine of the Fetus and Mother. ed 2. Philadelphia: Lippincott-Raven Publishers; 1999;p. 29–35
  69. He YG, Alizadeh H, Kinoshita K, McCulley JP. Experimental transplantation of cultured human limbal and amniotic epithelial cells on to the corneal surface. Cornea. 1999;18:570–579
  70. Honavar SG, Bansal AK, Sangwan VS, Rao GN. Amniotic membrane transplantation for ocular surface reconstruction in Stevens-Johnson syndrome. Ophthalmology. 2000;107:975–979
  71. Houlihan JM, Biro PA, Harper HM. The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G. J Immunol. 1995;154:5665–5674
  72. Hsi BL, Fredj-Reygrobellet D, Yeh CJ. Monoclonal antibodies to human amnion recognize different components of the rabbit eye. Invest Ophthalmol Vis Sci. 1986;27:620–622
  73. Hsi BL, Yeh CJ, Faulk WP. Human amniochorion: tissue-specific markers, transferrin receptors and histocompatibility antigens. Placenta. 1982;3:1–12
  74. Hsu CD, Meaddough E, Lu LC. Immunohistochemical localization of inducible nitric oxide synthase on human fetal amnion in intra-amniotic infection. Am J Obstet Gynecol. 1998;179:1271–1274
  75. Ishihara O, Saitoh M, Kinoshita K. Friegen II improves the reliability of measurement of interleukin-1 related substances in amniotic fluid. Acta Obstet Gynecol Scand. 1999;78:321–325
  76. Jones SA, Challis JR. Local stimulation of prostaglandin production by corticotropin-releasing hormone in human fetal membranes and placenta. Biochem Biophys Res Commun. 1989;159:192–199
  77. Joseph A, Dua HS, King AJ. Failure of amniotic membrane transplantation in treatment of acute chemical burns. Br J Ophthalmol. 2001;85:1065–1069
  78. Keelan JA, Sato T, Mitchell MD. Interleukin (IL)-6 and IL-8 production by human amnion: regulation by cytokines, growth factors, glucocorticoids, phorbol esters, and bacterial lipopolysaccharide. Biol Reprod. 1997;57:1438–1444
  79. Keelan JA, Sato TA, Hansesn WR. Interleukin-4 differentially regulates prostaglandin production in amnion-derived WISH cells stimulated with pro-inflammatory cytokines and epidermal growth factor. Prostaglandins Leukot Essent Fatty Acids. 1999;60:255–262
  80. Keene DR, Sakai LY, Lunstrum GP. Type VII collagen forms an extended network of anchoring fibrils. J Cell Biol. 1987;104:611–621
  81. Khodadoust AA, Silverstein AM, Kenyon DR, Dowling JE. Adhesion of regenerating corneal epithelium. The role of basement membrane. Am J Ophthalmol. 1968;65:339–348
  82. Kim JC, Tseng SC. The effects on inhibition of corneal neovascularization after human amniotic membrane transplantation in severely damaged rabbit corneas. Korean J Ophthalmol. 1995;9:32–46
  83. Kim JC, Tseng SCG. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea. 1995;14:473–484
  84. Kim JS, Kim JC, Na BK. Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Exp Eye Res. 2000;70:329–337
  85. Kjaergaard N, Hein M, Hyttel L. Antibacterial properties of human amnion and chorion in vitro. Eur J Obstet Gynecol Reprod Biol. 2001;94:224–229
  86. Kjaergaard N, Helmig RB, Schonheyder HC. Chorioamniotic membranes constitute a competent barrier to group B streptococcus in vitro. Eur J Obstet Gynecol Reprod Biol. 1999;83:165–169
  87. Koizumi N, Fullwood NJ, Bairaktaris G. Cultivation of corneal epithelial cells on intact and denuded human amniotic membrane. Invest Ophthalmol Vis Sci. 2000;41:2506–2513
  88. Koizumi N, Inatomi T, Quantock AJ. Amniotic membrane as a substrate for cultivating limbal corneal epithelial cells for autologous transplantation in rabbits. Cornea. 2000;19:65–71
  89. Koizumi NJ, Inatomi TJ, Sotozono CJ. Growth factor mRNA and protien in preserved human amniotic membrane. Curr Eye Res. 2000;20:173–177
  90. Kruse FE, Joussen AM, Rohrschneider K. Cryopreserved human amniotic membrane for ocular surface reconstruction. Graefes Arch Clin Exp Ophthalmol. 2000;238:68–75
  91. Kruse FE, Rohrschneider K, Volcker HE. Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers. Ophthalmology. 1999;106:1504–1510
  92. Kruse FE, Rohrschneider K, Volcker HE. Techniques for reconstruction of the corneal surface by transplantation of preserved amniotic membrane. Ophthalmologe. 1999;96:673–678
  93. Kruse FE, Rohrschneider K, Volcker HE. Transplantation of amniotic membrane for reconstruction of the eye surface. Ophthalmologe. 1998;95:114–119
  94. Kubo M, Sonada Y, Muramatsu R, Usui M. Immunogenicity of human amniotic membrane in experimental xenotransplantation. Invest Ophthalmol Vis Sci. 2001;42:1539–1546
  95. Kurpakus MA, Daneshvar C, Davenport J, Kim A. Human corneal epithelial cell adhesion to laminins. Curr Eye Res. 1999;19:106–114
  96. Kurpakus MA, Stock EL, Jones JC. The role of the basement membrane in differential expression of keratin proteins in epithelial cells. Dev Biol. 1992;150:243–255
  97. Lee HS, Kim JC. Effect of amniotic fluid in corneal sensitivity and nerve regeneration after excimer laser ablation. Cornea. 1996;15:517–524
  98. Lee JH, Wee WR, Chung ES. Development of a newly designed double-fixed Seoul-type keratoprosthesis. Arch Ophthalmol. 2000;118:1673–1678
  99. Lee SB, Li DQ, Tan DT. Suppression of TGF-beta signalling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane. Curr Eye Res. 2000;20:325–334
  100. Lee SH, Tseng SC. Amniotic membrane transplantation for persistent epithelial defects with ulceration. Am J Ophthalmol. 1997;123:303–312
  101. Letko E, Stechschulte SU, Kenyon KR. Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers. Arch Ophthalmol. 2001;119:659–663
  102. Linnala A, Balza E, Zardi L, Virtanen I. Human amnion epithelial cells assemble tenascins and three fibronectin isoforms in the extracellular matrix. FEBS Lett. 1993;317:74–78
  103. Ma DH, See LC, Liau SB, Tsai RJ. Amniotic membrane graft for primary pterygium: comparison with conjunctival autograft and topical mitomycin C treatment. Br J Ophthalmol. 2000;84:973–978
  104. Malak TM, Bell SC. Differential expression of the integrin subunits in human fetal membranes. J Reprod Fertil. 1994;102:269–276
  105. Maral T, Borman H, Arslan H. Effectiveness of human amnion preserved long-term in glycerol as a temporary biological dressing. Burns. 1999;25:625–635
  106. Marshall L, Ghosh MM, Boyce SG. Effects of glycerol on intracellular virus survival: implications for the clinical use of glycerol-preserved cadaver skin. Burns. 1995;21:356–361
  107. Martinez Pardo ME, Reyes Frias ML, Ramos Duron LE. Clinical application of amniotic membranes on a patient with epidermolysis bullosa. Ann Transplant. 1999;4:68–73
  108. Marvin KW, Hansen WR, Miller HC. Amnion-derived cells express intercellular adhesion molecule-1: regulation by cytokines. J Mol Endocrinol. 1999;22:193–205
  109. Matthews RN, Faulk WP, Bennett JP. A review of the role of amniotic membranes in surgical practice. Obstet Gynecol Annu. 1982;11:31–58
  110. Meek MF, Coert JH, Nicolai JP. Amnion tube for nerve regeneration. Plast Reconstr Surg. 2001;107:622–623
  111. Meinert M, Eriksen GV, Petersen AC, et al.  Proteoglycans and hyaluronan in human fetal membranes. Am J Obstet Gynecol. 2001;184:679–685
  112. Mejia LF, Acosta C, Santamaria JP. Use of nonpreserved human amniotic membrane for the reconstruction of the ocular surface. Cornea. 2000;19:288–291
  113. Meller D, Maskin SL, Pires RT, Tseng SC. Amniotic membrane transplantation for symptomatic conjunctivochalasis refractory to medical treatments. Cornea. 2000;19:796–803
  114. Meller D, Pires RTF, Mack RJS. Amniotic membrane transplantation for acute chemical or thermal burns. Ophthalmology. 2000;107:980–990
  115. Meller D, Pires RTF, Tseng SC. Ex vivo preservation and expansion of human limbal epithelial cells by amniotic membrane. Invest Ophthalmol Vis Sci. 1999;40:329
  116. Meller D, Tseng SC. Amniotic membrane transplantation with or without limbal allografts in corneal surface reconstruction in limbal deficiency. Ophthalmologe. 2000;97:100–107
  117. Meller D, Tseng SC. Conjunctival epithelial cell differentiation on amniotic membrane. Invest Ophthalmol Vis Sci. 1999;40:878–886
  118. Meller D, Tseng SC. In vitro conjunctival epithelial differentiation on preserved human amniotic membrane. Invest Ophthalmol Vis Sci. 1998;39:428
  119. Meller D, Tseng SC. Reconstruction of the conjunctival and corneal surface. Transplantation of amniotic membrane. Ophthalmologe. 1998;95:805–813
  120. Modesti A, Scarpa S, Dorazi G. Localization of type IV and V collagens in the stroma of human amnion. Prog Clin Biol Res. 1989;296:459–463
  121. Mohammad J, Shenaq J, Rabinovsky E, Shenaq S. Modulation of peripheral nerve regeneration: a tissue-engineering approach. The role of amnion tube nerve conduit across a 1-centimeter nerve gap. Plast Reconstr Surg. 2000;105:660–666
  122. Mohammad J, Warnke PH, Pan YC, Shenaq S. Increased axonal regeneration through a biodegradable amnionic tube nerve conduit: effect of local delivery and incorporation of nerve growth factor/hyaluronic acid media. Ann Plast Surg. 2000;44:59–64
  123. Muhlhauser J, Crescimanno C, Rajaniemi H. Immunohistochemistry of carbonic anhydrase in human placenta and fetal membranes. Histochemistry. 1994;101:91–98
  124. Muralidharan S, Gu J, Laub GW. A new biological membrane for pericardial closure. J Biomed Mater Res. 1991;25:1201–1209
  125. Murube J, Olivares C, Murube E. Treatment of dry eye by punctum patch. Orbit. 1995;14:1–7
  126. Nanbu Y, Fujii S, Konishi I. CA 125 in the epithelium closely related to the embryonic ectoderm: the periderm and the amnion. Am J Obstet Gynecol. 1989;161:462–467
  127. Nisolle M, Donnez J. Vaginoplasty using amniotic membranes in cases of vaginal agenesis or after vaginectomy. J Gynecol Surg. 1992;8:25–30
  128. Ocklesford CD, Malak T, Hubbard A. Human amniochorion cytoskeletons at term. Placenta. 1993;14:A56
  129. Otsuki K, Yoda A, Saito H. Amniotic fluid lactoferrin in intrauterine infection. Placenta. 1999;20:175–179
  130. Panda A. Amniotic membrane transplantation in ophthalmology (fresh v preserved tissue). Br J Ophthalmol. 1999;83:1410–1411
  131. Park WC, Tseng SC. Modulation of acute inflammation and keratocyte death by suturing, blood and amniotic membrane in PRK. Invest Ophthalmol Vis Sci. 2000;41:2906–2914
  132. Paridaens D, Beekhuis H, van Den Bosch W. Amniotic membrane transplantation in the management of conjunctival malignant melanoma and primary acquired melanosis with atypia. Br J Ophthalmol. 2001;85:658–661
  133. Pellegrini G, Traverso CE, Franzi AT. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet. 1997;349:990–993
  134. Pires RTF, Chokshi A, Tseng SCG. Amniotic membrane transplantation or conjunctival limbal autograft for stem cell deficiency induced by 5-fluorouracil in glaucoma surgeries. Cornea. 2000;19:284–287
  135. Pires RT, Tseng SC, Prabhasawat P. Amniotic membrane transplantation for symptomatic bullous keratopathy. Arch Ophthalmol. 1999;117:1291–1297
  136. Pollard SM, Aye NN, Symonds EM. Scanning electron microscope appearances of normal human amnion and umbilical cord at term. Br J Obstet Gynaecol. 1976;83:470–477
  137. Prabhasawat P, Barton K, Burkett G, Tseng SC. Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision. Ophthalmology. 1997;104:974–985
  138. Prabhasawat P, Tseng SC. Impression cytology study of epithelial phenotype of ocular surface reconstructed by preserved human amniotic membrane. Arch Ophthalmol. 1997;115:1360–1367
  139. Prasad JK, Feller I, Thomson PD. Use of amnion for the treatment of Stevens-Johnson syndrome. J Trauma. 1986;26:945–946
  140. Quinby WC, Hoover HC, Schefian M. Clinical trials of amniotic membranes in burn wound care. Plast Reconstr Surg. 1982;70:711–716
  141. Rakowska E, Zagorski Z, Kardaszewska A, Durakiewicz D. Application of amniotic membrane transplantation in severe corneal diseases. Klin Oczna. 1999;101:417–421
  142. Rao CV, Carman FR, Chegini N, Schultz GS. Binding sites for epidermal growth factor in human fetal membranes. J Clin Endocrinol Metab. 1984;58:1034–1042
  143. Rao TV, Chandrasekharam V. Use of dry human and bovine amnion as a biological dressing. Arch Surg. 1981;116:891–896
  144. Rees MC, Di MV, Lopez BA. Leukotriene release by human fetal membranes, placenta and decidua in relation to parturition. J Endocrinol. 1988;118:497–500
  145. Reisenberger K, Egarter C, Knofler M. Cytokine and prostaglandin production by amnion cells in response to the addition of different bacteria. Am J Obstet Gynecol. 1998;178:50–53
  146. Rennekampff HO, Dohrmann P, Fory R, Fandrich F. Evaluation of amniotic membrane as adhesion prophylaxis in a novel surgical gastroschisis model. J Invest Surg. 1994;7:187–193
  147. Robson MC, Krizek TJ. The effect of human amniotic membranes on the bacteria population of infected rat burns. Ann Surg. 1973;177:144–149
  148. Robson MC, Samburg JL, Krizek TJ. Quantitative comparison of biological dressings. Surg Forum. 1972;23:503–505
  149. Rodriguez-Ares MT, Tourino R, Capeans C, Sanchez-Salorio M. Repair of scleral perforation with preserved scleral and amniotic membrane in Marfan's syndrome. Ophthalmic Surg Lasers. 1999;30:485–487
  150. Roper-Hall MJ. Thermal and chemical burns. Trans Ophthalmol Soc UK. 1965;85:631–653
  151. Rosenthal P, Cotter JM, Baum J. Treatment of persistent corneal epithelial defect with extended wear of a fluid-ventilated gas-permeable scleral contact lens. Am J Ophthalmol. 2000;130:33–41
  152. Rote NS, Menon R, Swan KF, Lynden TW. Expression of IL-1 and IL-6 protein and mRNA in amniochorionic membranes. Placenta. 1993;14:A63
  153. Rowe TF, King LA, MacDonald PC, Casey ML. Tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 expression in human amnion mesenchymal and epithelial cells. Am J Obstet Gynecol. 1997;176:915–921
  154. Runic R, Lockwood CJ, LaChapelle L. Apoptosis and Fas expression in human fetal membranes. J Clin Endocrinol Metab. 1998;83:660–666
  155. Sabella W. Use of fetal membranes in skin grafting. Med Rec NY. 1913;83:478–480
  156. Sakuragawa N, Elwan MA, Uchida S. Non-neuronal neurotransmitters and neurotrophic factors in amniotic epithelial cells: expression and function in humans and monkey. Jpn J Pharmacol. 2001;85:20–23
  157. Schilling B, Yeh J. Transforming growth factor-beta(1), -beta(2), -beta(3) and their type I and II receptors in human term placenta. Gynecol Obstet Invest. 2000;50:19–23
  158. Schofield OM, McDonald JN, Fredj-Reygrobellet D. Common antigen expression between human periderm and other tissues identified by GB1-monoclonal antibody. Arch Dermatol Res. 1990;282:143–148
  159. Schwab IR. Cultured corneal epithelia for ocular surface disease. Trans Am Ophthalmol Soc. 1999;97:891–896
  160. Schwab IR, Reyes M, Isseroff RR. Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea. 2000;19:421–426
  161. Shimazaki J, Shinozaki N, Tsubota K. Transplantation of amniotic membrane and limbal autograft for patients with recurrent pterygium associated with symblepharon. Br J Ophthalmol. 1998;82:235–240
  162. Shimazaki J, Yang HY, Tsubota K. Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns. Ophthalmology. 1997;104:2068–2076
  163. Shimazaki J, Shimmura S, Fujishima H, Tsubota K. Association of preoperative tear function with surgical outcome in severe Stevens-Johnson syndrome. Ophthalmology. 2000;107:1518–1523
  164. Shimmura S, Shimazaki J, Ohashi Y, Tsubota K. Antiinflammatory effects of amniotic membrane transplantation in ocular surface disorders. Cornea. 2001;20:408–413
  165. Silverton JS, Trelford JD, Roussere JT. The use of amniotic membrane in acute massive full-thickness loss of the abdominal wall from clostridial myonecrosis. Ann Plast Surg. 1979;3:558–566
  166. Simmonds RJ, Holmberg SD, Hurwitz RL. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. N Engl J Med. 1992;326:726–732
  167. Smieja Z, Zakar T, Walton JC, Olson DM. Prostaglandin endoperoxide synthase kinetics in human amnion before and after labor at term and following preterm labor. Placenta. 1993;14:163–175
  168. Solomon A, Pires RT, Tseng SC. Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia. Ophthalmology. 2001;108:449–460
  169. Solomon A, Rosenblatt M, Monroy D. Suppression of interleukin 1alpha and interleukin 1 beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix. Br J Ophthalmol. 2001;85:444–449
  170. Sonnenberg A, Calafat J, Janssen H. Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. J Cell Biol. 1991;113:907–917
  171. Sorsby A, Haythorne J, Reed H. Further experience with amniotic membrane grafts in caustic burns of the eye. Br J Ophthalmol. 1947;31:409–418
  172. Sorsby A, Symmons HM. Amniotic membrane grafts in caustic burns of the eye (burns of second degree). Br J Ophthalmol. 1946;30:337–345
  173. Sridhar MS, Bansal AK, Sangwan VA, Rao GN. Amniotic membrane transplantation in acute chemical and thermal injury. Am J Ophthalmol. 2000;130:134–137
  174. Sridhar MS, Sangwan VA, Bansal AK, Rao GN. Amniotic membrane transplantation in the management of shield ulcers of vernal keratoconjunctivitis. Ophthalmology. 2001;108:1218–1222
  175. Steinkogler FJ, Haddad R. Conjunctival replacement—comparative animal experiment study. Klin Monatsbl Augenheilkd. 1985;187:359–360
  176. Stern W. The grafting of preserved amniotic membrane to burned and ulcerated skin. JAMA. 1913;13:973–974
  177. Streuli CH, Bailey N, Bissell MJ. Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J Cell Biol. 1991;115:1383–1395
  178. Su CY, Lin CP. Combined use of an amniotic membrane and tissue adhesive in treating corneal perforation: a case report. Ophthalmic Surg Lasers. 2000;31:151–154
  179. Subrahmanyam M. Amniotic membrane as a cover for microskin grafts. Br J Plast Surg. 1995;48:477–478
  180. Sutton L, Gadd M, Masson DY, Redman CW. Cells bearing class II MHC antigens in the human placenta and amniochorion. Immunology. 1986;58:23–29
  181. Talmi YP, Sigler L, Inge E. Antibacterial properties of human amniotic membranes. Placenta. 1991;12:285–288
  182. Terranova VP, Lyall RM. Chemotaxis of human gingival epithelial cells to laminin. A mechanism for epithelial cell apical migration. J Periodontol. 1986;57:311–317
  183. Ti S, Tow SLC, Chee S. Amniotic membrane transplantation in entropion surgery. Ophthalmology. 2001;108:1209–1217
  184. Toth P, Li X, Rao CV. Expression of hCG/LH receptor gene and its functional coupling to the regulation of cyclo-oxygenase-1 and -2 enzymes in human fetal membranes. Placenta. 1993;14:A78
  185. Toth P, Rao CV. Direct novel regulation of cyclooxygenase (COX) and prostacyclin synthase (PGI2-S) by hCG in human amnion. Placenta. 1992;13:A63
  186. Trelford JD, Trelford-Sauder M. The amnion in surgery, past and present. Am J Obstet Gynecol. 1979;134:833–845
  187. Trelford-Sauder M, Dawe EJ, Trelford JD. Use of allograft amniotic membrane for control of intra-abdominal adhesions. J Med. 1978;9:273–284
  188. Troensagaard-Hansen E. Amniotic grafts in chronic skin ulceration. Lancet. 1950;1:859–860
  189. Tsai RJ, Li LM, Chen JK. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N Engl J Med. 2000;343:86–93
  190. Tseng SC, Li DQ, Ma X. Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol. 1999;179:325–335
  191. Tseng SC, Prabhasawat P, Barton K. Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch Ophthalmol. 1998;116:431–441
  192. Tseng SC, Prabhasawat P, Lee SH. Amniotic membrane transplantation for conjunctival surface reconstruction. Am J Ophthalmol. 1997;124:765–774
  193. Tsubota K, Satake Y, Kaido M, et al.  Treatment of severe ocular surface disorders with corneal epithelial stem cell transplantation. N Eng J Med. 1999;22:1697–1703
  194. Tsubota K, Satake Y, Ohyama M. Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Am J Ophthalmol. 1996;122:38–52
  195. Tsubota K, Satake Y, Shimazaki J. Treatment of severe dry eye. Lancet. 1996;348:123
  196. Tsubota K, Shimazaki J. Surgical treatment of children blinded by Stevens-Johnson syndrome. Am J Ophthalmol. 1999;128:573–581
  197. Tyszkiewicz JT, Uhrynowska-Tyszkiewicz IA, Kaminski A, Dziedzic-Goclawska A. Amnion allografts prepared in the central tissue bank in Warsaw. Ann Transplant. 1999;4:85–90
  198. Uchida S, Inanaga Y, Kobayashi M. Neurotrophic function of conditioned medium from human amniotic epithelial cells. J Neurosci Res. 2000;62:585–590
  199. van Baare J, Ligtvoet EEJ, Middelkoop E. Microbiological evaluation of glycerolized cadaveric donor skin. Transplantation. 1998;65:966–970
  200. van Baare J, Buitenwerf J, Hoekstra MJ, du Pont JS. Virucidal effect of glycerol as used in donor skin preservation. Burns. 1994;20:77–80
  201. van Herendael BJ, Oberti C, Brosens I. Microanatomy of the human amniotic membranes. A light microscopic, transmission, and scanning electron microscopic study. Am J Obstet Gynecol. 1978;131:872–880
  202. Walsh H, Hildebrandt RJ, Prystowsky H. Growth inhibition factors in amniotic fluid. Am J Obstet Gynecol. 1965;93:590–591
  203. Wang MX, Gray TB, Park WC. Reduction in corneal haze and apoptosis by amniotic membrane matrix in excimer laser photoablation in rabbits. J Cataract Refract Surg. 2001;27:310–319
  204. Ward DJ, Bennett JP, Burgos H, Fabre J. The healing of chronic venous leg ulcers with prepared human amnion. Br J Plast Surg. 1989;42:463–467
  205. Ward DJ, Bennett JP. The long-term results of the use of human amnion in the treatment of leg ulcers. Br J Plast Surg. 1984;37:191–193
  206. Weser H, Kaufmann P. [Light microscopical and histochemical studies on the chorionic plate of the mature human placenta (authors transl)]. Arch Gynakol. 1978;225:15–30
  207. Wolf HJ, Desoye G. Immunohistochemical localization of glucose transporters and insulin receptors in human fetal membranes at term. Histochemistry. 1993;100:379–385
  208. Wolf HJ, Schmidt W, Drenckhahn D. Immunocytochemical analysis of the cytoskeleton of the human amniotic epithelium. Cell Tissue Res. 1991;266:385–389
  209. Woo HM, Kim MS, Kweon OK. Effects of amniotic membrane on epithelial wound healing and stromal remodelling after excimer laser keratectomy in rabbit cornea. Br J Ophthalmol. 2001;85:345–349
  210. Yotis W, Stanke R. Bacteriostatic action of progesterone on staphylococci and other microorganisms. J Bacteriol. 1966;92:1285–1289
  211. Young RL, Cota J, Zund G. The use of an amniotic membrane graft to prevent postoperative adhesions. Fertil Steril. 1991;55:624–628
  212. Yurchenco PD, Ruben GC. Basement membrane structure in situ: evidence for lateral associations in the type IV collagen network. J Cell Biol. 1987;105:2559–2568
  213. Zhang Q, Shimoya K, Moriyama A. Production of secretory leukocyte protease inhibitor by human amniotic membranes and regulation of its concentration in amniotic fluid. Mol Hum Reprod. 2001;7:573–579
  214. Zohar Y, Talmi YP, Finkelstein Y. Use of human amniotic membrane in otolaryngologic practice. Laryngoscope. 1987;97:978–980

 The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article.

PII: S0039-6257(03)00126-7

doi: 10.1016/j.survophthal.2003.10.004

Survey of Ophthalmology
Volume 49, Issue 1 , Pages 51-77 , January 2004