Survey of Ophthalmology
Volume 49, Issue 4 , Pages 419-428, July 2004

Sunlight exposure and pathogenesis of uveal melanoma☆

  • Arun D Singh, MD, FRCS, FRCOphth

      Affiliations

    • Corresponding Author InformationReprint address: Arun D. Singh, MD, Department of Ophthalmic Oncology, Cole Eye Institute (i3-129), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195.
    • ,
  • Ian G Rennie, FRCS, FRCOphth

      Affiliations

    • ,
  • Stefan Seregard, MD

      Affiliations

    • ,
  • Michael Giblin, MD

      Affiliations

    • ,
  • John McKenzie, MD

      Affiliations

1Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; 2Department of Ophthalmology and Orthoptics, Royal Hallamshire Hospital, Sheffield, United Kingdom; 3St Erik's Eye Hospital, and Karolinska Institute, Stockholm, Sweden; 4Sydney Eye Hospital, Sydney, Australia; and 5East Melbourne Eye Group, Melbourne, Australia

JOHANNA SEDDON AND DONALD FONG, EDITORS

Abstract 

Uveal melanoma is the most frequent primary malignant intraocular tumor of adults. Among various non-modifiable risk factors, Caucasian race seems to be the most significant with light skin color, blond hair, and blue eyes being specific risk factors. The racial predisposition to uveal melanoma have been explained on the basis of susceptibility of Caucasian race to oncogenic effects of sunlight. Although there is ample evidence in support of this hypothesis in regard to skin melanoma, the evidence in regard to uveal melanoma is insufficient and contradictory. In the following review, we examine physiologic, epidemiological, and genetic data in order to determine the role of sunlight exposure in the pathogenesis of uveal melanoma.

Keywords:  melanoma, sunlight, ultraviolet light, uvea, uveal melanoma

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☆ The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article

PII: S0039-6257(04)00089-X

doi:10.1016/j.survophthal.2004.04.009

Survey of Ophthalmology
Volume 49, Issue 4 , Pages 419-428, July 2004

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