Survey of Ophthalmology
Volume 51, Issue 2 , Pages 162-168 , March 2006

Plexiform Pigmented Schwannoma of the Uvea

  • Egbert Saavedra, MD

      Affiliations

    • Cole Eye Institute
    • ,
  • Arun D. Singh, MD

      Affiliations

    • Cole Eye Institute
    • Corresponding Author InformationReprint address: Arun D. Singh, MD, Department of Ophthalmic Oncology, Cole Eye Institute (i3-129), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195.
    • ,
  • Jonathan E. Sears, MD

      Affiliations

    • Cole Eye Institute
    • ,
  • Norman B. Ratliff, MD

      Affiliations

    • Department of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

References 

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  2. Carney JA. The Carney complex (myxomas, spotty pigmentation, endocrine overactivity, and schwannomas). Dermatol Clin. 1995;13:19–26
  3. Carney JA. Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol. 1990;14:206–222
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  6. Freedman SF, Elner VM, Donev I, et al. Intraocular neurilemmoma arising from the posterior ciliary nerve in neurofibromatosis. Pathologic findings. Ophthalmology. 1988;95:1559–1564
  7. Gunduz K, Shields CL, Shields JA, Singh AD. Iris mamillations as the only sign of ocular melanocytosis in a child with choroidal melanoma. Arch Ophthalmol. 2000;118:716–717
  8. Honavar SG, Shields CL, Singh AD, et al. Two discrete choroidal melanomas in an eye with ocular melanocytosis. Surv Ophthalmol. 2002;47:36–41
  9. Jacoby LB, Jones D, Davis K, et al. Molecular analysis of the NF2 tumor-suppressor gene in schwannomatosis. Am J Hum Genet. 1997;61:1293–1302
  10. Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM. The pathobiologic spectrum of Schwannomas. Histol Histopathol. 2003;18:925–934
  11. Luse SA. Electron microscopic studies of brain tumors. Neurology. 1960;10:881–905
  12. MacCollin M, Willett C, Heinrich B, et al. Familial schwannomatosis: exclusion of the NF2 locus as the germline event. Neurology. 2003;60:1968–1974
  13. Mennemeyer RP, Hallman KO, Hammar SP, et al. Melanotic schwannoma. Clinical and ultrastructural studies of three cases with evidence of intracellular melanin synthesis. Am J Surg Pathol. 1979;3:3–10
  14. Reith JD, Goldblum JR. Multiple cutaneous plexiform schwannomas. Report of a case and review of the literature with particular reference to the association with types 1 and 2 neurofibromatosis and schwannomatosis. Arch Pathol Lab Med. 1996;120:399–401
  15. Shields JA, Font RL, Eagle RC, et al. Melanotic schwannoma of the choroid. Immunohistochemistry and electron microscopic observations. Ophthalmology. 1994;101:843–849
  16. Singh AD, De Potter P, Fijal B, et al. Lifetime prevalence of uveal melanoma in caucasian patients with oculo(dermal) melanocytosis. Ophthalmology. 1998;105:195–198
  17. Singh AD, Shields CL, Shields JA, Sato T. Uveal melanoma in young patients. Arch Ophthalmol. 2000;118:918–923
  18. In:  Weiss SW,  Goldblum JR editor. Enzinger and Weiss's Soft tissue tumors. St Louis, Missouri: Mosby, Inc.; 2003;ed 4,

 The authors reported no proprietary or commercial interest in any products mentioned or concepts discussed in this article.

PII: S0039-6257(05)00209-2

doi: 10.1016/j.survophthal.2005.12.004

Survey of Ophthalmology
Volume 51, Issue 2 , Pages 162-168 , March 2006

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