Survey of Ophthalmology
Volume 51, Issue 4 , Pages 419-433 , July 2006

Conjunctival Amyloidosis: Report of Six Cases and Review of the Literature

  • Hakan Demirci, MD

      Affiliations

    • Oncology Service
  • ,
  • Carol L. Shields, MD

      Affiliations

    • Oncology Service
    • Corresponding Author InformationReprint address: Carol L. Shields, M.D., Oncology Service, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA 19107.
  • ,
  • Ralph C. Eagle Jr., MD

      Affiliations

    • Pathology Department, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  • ,
  • Jerry A. Shields, MD

      Affiliations

    • Oncology Service

References 

  1. Bisaria KK, Garg KC, Sud SD. Paralimbal amyloid tumour. Br J Ophthalmol. 1967;51:136–137
  2. Blodi FC, Apple DJ. Localized conjunctival amyloidosis. Am J Ophthalmol. 1979;88:346–350
  3. Borodic GE, Beyer-Machule CK, Millin J, et al. Immunoglobulin deposition in localized conjunctival amyloidosis. Am J Ophthalmol. 1984;98:617–622
  4. Brozou CG, Baglivo E, de Gottrau P, et al. Chronic hyposphagma revealing primary ocular amyloidosis. Klin Monatsbl Augenheilkd. 2003;220:196–198
  5. Chaturvedi P, Lala M, Desai S, et al. A rare case of both eyelids swelling: isolated conjunctival amyloidosis. Indian J Ophthalmol. 2000;48:56–57
  6. Cheong-Leen R. Primary localised conjunctival amyloidosis presenting as subconjunctival haemorrhage. Eye. 2001;15:679–680
  7. Cohen AS. Amyloidosis. In:  Braunwald E,  Fauci AS,  Isselbaher KJ, et al. editor. Harrison's Principle of Internal Medicine. New York: McGraw-Hill; 1998;ed 14, pp 1417–21
  8. Dithmar S, Linke RP, Kolling G, et al. Ptosis from localized A-lambda-amyloid deposits in the levator palpebrae muscle. Ophthalmology. 2004;111:1043–1047
  9. Elles NB. Amyloid disease of the conjunctiva. Am J Ophthalmol. 1945;28:486–497
  10. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med. 1997;337:898–909
  11. Gertz MA, Lacy MQ, Dispenzieri A. Amyloidosis. Hematol Oncol Clin North Am. 1999;13:1211–1233
  12. Glass R, Scheie HG, Yanoff M. Conjunctival amyloidosis arising from a plasmacytoma. Ann Ophthalmol. 1971;3:823–825
  13. Glenner GG, Terry W, Harada M, et al. Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses. Science. 1971;172:1150–1151
  14. Grossniklaus HE, Green WR, Luckenbach M, et al. Conjunctival lesions in adults. A clinical and histopathologic review. Cornea. 1987;6:78–116
  15. Guerry D, Weisinger H. Amyloid disease of the conjunctiva and tarsus. Am J Ophthalmol. 1960;49:1413–1415
  16. Herndon BW. Perilimbal amyloid tumor. Am J Ophthalmol. 1968;66:515–520
  17. Hill VE, Brownstein S, Jordan DR. Ptosis secondary to amyloidosis of the tarsal conjunctiva and tarsus. Am J Ophthalmol. 1997;123:852–854
  18. Iijima S. Primary systemic amyloidosis: a unique case complaining of diffuse eyelid swelling and conjunctival involvement. J Dermatol. 1992;19:113–118
  19. Jensen JE. Localized amyloidosis in relation to conjunctival haemorrhagic lymphangiectasia and occlusion of the orbital veins. A case report. Acta Ophthalmol (Copenh). 1983;61:254–260
  20. Kiratli H, Shields CL, Shields JA, et al. Metastatic tumours to the conjunctiva: report of 10 cases. Br J Ophthalmol. 1996;80:5–8
  21. Knowles DM, Jakobiec FA, Rosen M, et al. Amyloidosis of the orbit and adnexae. Surv Ophthalmol. 1975;19:367–384
  22. Kyle RA, Greipp PR. Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc. 1983;58:665–683
  23. Kyle RA, Linos A, Beard CM, et al. Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992;79:1817–1822
  24. Lamkin JC, Jakobiec FA. Amyloidosis of the eye. In:  Albert DM,  Jakobiec FA editor. Principles and Practice of Ophthalmology. Philadelphia: WB Saunders; 1994;p. 2956–2975
  25. Lee HM, Naor J, DeAngelis D, et al. Primary localized conjunctival amyloidosis presenting with recurrence of subconjunctival hemorrhage. Am J Ophthalmol. 2000;129:245–247
  26. Madangopal AV. Conjunctival amyloidosis. Br J Ophthalmol. 1962;46:749–752
  27. Marsh WM, Streeten BW, Hoepner JA, et al. Localized conjunctival amyloidosis associated with extranodal lymphoma. Ophthalmology. 1987;94:61–64
  28. Mathur SP, Mathur BP. Conjunctival amyloidosis. Br J Ophthalmol. 1959;43:765–766
  29. McLendon WW: Kenneth M. Brinkhous, MD. The fifth editor of the Archives of Pathology and Laboratory Medicine. Arch Pathol Lab Med 107:617–8, 1983
  30. Meisler DM, Stock EL, Wertz RD, et al. Conjunctival inflammation and amyloidosis in allergic granulomatosis and angiitis (Churg-Strauss syndrome). Am J Ophthalmol. 1981;91:216–219
  31. Moorman CM, McDonald B. Primary (localised non-familial) conjunctival amyloidosis: three case reports. Eye. 1997;11:603–606
  32. Nau JA, Shields CL, Shields JA, et al. Clinicopathologic reports, case reports, and small case series: acute myeloid leukemia manifesting initially as a conjunctival mass in a patient with acquired immunodeficiency syndrome. Arch Ophthalmol. 2002;120:1741–1742
  33. Norn MS. Conjunctival amyloidosis. Acta Ophthalmol. 1964;42:1054–1062
  34. O'Donnell B, Wuebbolt G, Collin R. Amyloidosis of the conjunctiva. Aust NZ J Ophthalmol. 1995;23:207–212
  35. Patrinely JR, Koch DD. Surgical management of advanced ocular adnexal amyloidosis. Arch Ophthalmol. 1992;110:882–885
  36. Pecora JL, Sambursky JS, Vargha Z. Radiation therapy in amyloidosis of the eyelid and conjunctiva: a case report. Ann Ophthalmol. 1982;14:194–196
  37. Pepys MB. Amyloidosis. In:  Weatherall DJ,  Ledingham JGG,  Warrell DA editor. Oxford Textbook of Medicine, Vol 2. Oxford: Oxford University Press; 1996;p. 1512–1524
  38. Pico G. Chronic pseudotumoral edema of the conjunctiva of possible myxedematous and amyloid origin: With report of two cases. Trans Amer Ophthalmol Soc. 1960;58:132–154
  39. Purcell JJ, Birkenkamp R, Tsai CC, et al. Conjunctival involvement in primary systemic nonfamilial amyloidosis. Am J Ophthalmol. 1983;95:845–847
  40. Richlin JJ, Kuwabara T. Amyloid disease of the eyelid and conjunctiva. Arch Ophthalmol. 1962;67:138–142
  41. Rodrigues MM, Cullen G, Shannon G. Primary localized conjunctival amyloidosis following strabismus surgery. Can J Ophthalmol. 1976;11:177–179
  42. Rosenblatt M, Spitz GF, Friedman AH, et al. Localized conjunctival amyloidosis: case reports and review of literature. Ophthalmologica. 1986;192:238–245
  43. Sandgren O. Ocular amyloidosis, with special reference to the hereditary forms with vitreous involvement. Surv Ophthalmol. 1995;40:173–196
  44. Schroeder FM, Miller FJ, Nelson JA, et al. Gastrointestinal angiographic findings in systemic amyloidosis. AJR Am J Roentgenol. 1978;131:143–146
  45. Shields CL, Shields JA, Carvalho C, et al. Conjunctival lymphoid tumors: clinical analysis of 117 cases and relationship to systemic lymphoma. Ophthalmology. 2001;108:979–984
  46. Shields JA, Eagle RC, Shields CL, et al. Systemic amyloidosis presenting as a mass of the conjunctival semilunar fold. Am J Ophthalmol. 2000;130:523–525
  47. Shields JA, Shields CL. Conjunctival amyloidosis. In:  Shields JA,  Shields CL editor. Atlas of Eyelid and Conjunctival Tumors. Philadelphia: Lippincott Williams and Williams; 1999;p. 324–325
  48. Smith ME, Zimmerman LE. Amyloidosis of the eyelid and conjunctiva. Arch Ophthalmol. 1966;75:42–51
  49. Van Cleynenbreugel H, Geerards AJ, Vreugdenhil W. The use of soft bandage contact lenses in the management of primary (localized non-familial) conjunctival amyloidosis: a case report. Bull Soc Belge Ophthalmol. 2002;285:45–50

 The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article. Support was provided by the Paul Kayser International Award of Merit in Retina Research, Houston, TX (J. Shields), Macula Foundation, New York, NY (C. Shields), the Noel T. and Sara L. Simmonds Endowment for Ophthalmic Pathology, Wills Eye Hospital (R. Eagle, Jr.) and the Eye Tumor Research Foundation, Philadelphia, PA (C. Shields).

PII: S0039-6257(06)00080-4

doi: 10.1016/j.survophthal.2006.04.007

Survey of Ophthalmology
Volume 51, Issue 4 , Pages 419-433 , July 2006