Survey of Ophthalmology
Volume 54, Issue 6 , Pages 697-704 , November 2009

Characteristics of Orbital Multiple Myeloma: A Case Report and Literature Review

References 

  1. Aboud N, Sullivan T, Whitehead K. Primary extramedullary plasmacytoma of the orbit. Aust NZ J Ophthalmol. 1995;23(3):235–239
  2. Adkins JW, Shields JA, Shields CL, et al. Plasmacytoma of the eye and orbit. Int Ophthal. 1996–7;20(6):339–343
  3. Ajithkumar TV, Sivasankar C, Ramachandran K. Orbital multiple myeloma: case report and review of computed tomography features. Australas Radiol. 2002;46:119–120
  4. Bataille R, Harousseau JL. Medical progress: multiple myeloma. New Engl J Med. 1997;336:1657–1664
  5. Benjamin I, Taylor H, Spindler J. Orbital and conjunctival involvement in multiple myeloma. Amer J Clin Pathol. 1975;63:811–817
  6. Boyadjis TA, D'Altorio RA. Orbital involvement by multiple myeloma: case report. J Comput Tomogr. 1986;10(2):145–146
  7. Carter C, Greaves M, Preston FE. Orbital plasmacytoma in established myeloma—a report of two cases. Clin Lab Haematol. 1986;8:155–159
  8. Chu JY, Lewis AJ, Cowan DH. IgDK multiple myeloma presenting as unilateral proptosis. Can J Neurol Sci. 1985;12:69–72
  9. Darbari BS, Bansal MC, Phadke SN. Bilateral orbital plasmacytoma. Indian J Ophthalmol. 1972;20:28–30
  10. De Smet MD, Rootman J. Orbital manifestations of plasmacytic lymphoproliferations. Ophthalmology. 1987;94(8):995–1003
  11. Ezra E, Mannor G, Writght JE, Rose GE. Inadequately irradiated solitary extramedullary plasmacytoma of the orbit requiring exenteration. Am J Ophthalmol. 1995;120(6):803–805
  12. Fay AM, Leib ML, Fountain KS. Multiple myeloma involving the orbit. Ophthal Plast Reconstr Surg. 1998;14(1):67–71
  13. Fung S, Selva D, Leibovitch I, et al. Ophthalmic manifestations of multiple myeloma. Ophthalmologica. 2005;219:43–48
  14. Goldstein DA, Schteingart MT, Birnbaum AD, et al. Bilateral eyelid ecchymoses and corneal crystals. Cornea. 2005;24(6):757–758
  15. Gonnering RS. Bilateral primary extramedullary orbital plasmacytomas. Ophthalmology. 1987;94(3):267–269
  16. Gonul E, Izci Y, Sefali M, et al. Orbital manifestation of multiple myeloma: case report. Minim Invas Neurosurg. 2001;44:172–174
  17. Greipp PR, San Miguel J, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23(15):3412–3420
  18. Henderson JW. Hematopoietic tumors. In:  Henderson JW,  Farrow GM,  Garrity JA editor. Orbital Tumors. New York: Raven Press, Ltd.; 1999;p. 294–296
  19. Howling SJ, Tighe J, Patterson K, et al. Case report: the CT features of orbital multiple myeloma. Clin Radiol. 1998;53:304–305
  20. Jackson A, Kwartz J, Noble JL, et al. Case report. Multiple myeloma presenting as bilateral orbital masses: CT and MR appearances. Br J Radiol. 1999;66:266–268
  21. Kelly SP, Lloyd IC, Anderson H, et al. Solitary extramedullary plasmacytoma of the maxillary antrum and orbit presenting as acute bacterial cellulites. Br J Ophthalmol. 1991;75:438–439
  22. Knapp AJ, Gartner S, Henkind P. Multiple myeloma and its ocular manifestations. Surv Ophthalmol. 1987;31(5):343–351
  23. Knecht P, Schuler R, Chaloupka K. Rapid progressive extramedullary plasmacytoma in the orbit. Klinische Monatsblatter fur Augenheilkunde. 2008;225(5):514–516
  24. Knowles DM, Halper JA, Trokel S, et al. Immunofluorescent and immunoperoxidase characteristics of IgD lambda myeloma involving the orbit. Am J Ophthalmol. 1978;85(4):485–494
  25. Kottler UB, Cursiefen C, Holbach LM. Orbital involvement in multiple myeloma: first sign of insufficient chemotherapy. Ophthalmologica. 2003;217:76–78
  26. Lazaridou MN, Micallef-Eynaud P, Hanna IT. Soft tissue plasmacytoma of the orbit as part of the spectrum of multiple myeloma. Orbit. 2007;26(4):315–318
  27. Lee HJ, Chang SE, Lee MW, et al. Systemic amyloidosis associated with multiple myeloma presenting as periorbital purpura. J Dermatol. 2008;35(6):371–372
  28. Levin SR, Spaulding AG, Wirman JA. Multiple myeloma: orbital involvement in a youth. Arch Ophthalmol. 1977;95:642–644
  29. McCann JD, Morschbacher R, Mamalis N, et al. Multiple myeloma presenting as honeycomb hyperostosis. Ann Ophthalmol–Glaucoma. 1999;31:306–308
  30. McFadzean RM. Orbital plasma cell myeloma. Brit J Ophthalmol. 1975;59:164–165
  31. Mewis-Levin L, Garcia CA, Olson JD. Plasma cell myeloma of the orbit. Ann Ophthalmol. 1981;477–481
  32. Munshi NC, Anderson KC. Cancer Principles and Practice. 7th ed. Philadelphia, PA, Lippincott: Williams and Wilkins; 2005;
  33. Nikoskelainen E, Dellaporta A, Rice T, et al. Orbital involvement by plasmacytoma. Acta Ophthalmol. 1976;54:755–761
  34. Omoti AE, Omoti CE. Ophthalmic manifestations of multiple myeloma. West Afr J Med. 2007;26(4):265–268
  35. Palamar M, Shields CL, Ghassemi F, et al. Choroidal plasmacytoma in a patient with multiple myeloma. Diagnosis by fine-needle aspiration biopsy. Graefes Arch Clin Experim Ophthalmol. 2008;246(8):1195–1197
  36. Plotnick H, Taniguchi Y, Hashimoto K, et al. Periorbital necrobiotic xanthogranuloma and stage I multiple myeloma. J Amer Acad Derm. 1991;25:373–377
  37. Price HI, Danziger A, Wainwright HC, et al. CT of orbital myeloma. Am J Neuroradiol. 1980;1:573–575
  38. Rawlings NG, Brownstein S, Robinson JW, Jordan DR. Solitary osseous plasmacytoma of the orbit with amyloidosis. Ophthal Plast Reconstr Surg. 2007;23(1):79–80
  39. Ries LAG, Melbert D, Krapcho M, et al, eds. SEER Cancer Statistics Review, 1975–2005. Bethesda, MD, National Cancer Institute. Available at http://seer.cancer.gov/csr/1975_2005/, based on November 2007 SEER data submission, posted to the SEER Web site: 2008
  40. Rodman HI, Font RL. Orbital involvement in multiple myeloma. Arch Ophthalmol. 1972;87:30–35
  41. Rootman J, White VA, Connors JM, et al. Lymphoproliferative, leukemic, and histiocytic lesions of the orbit. In:  Rootman J editors. Diseases of the Orbit. Philadelphia, PA, Lippincott: Williams and Wilkins; 2003;p. 402–406
  42. Rubenzik R, Tenzel R. Multiple myeloma involving the lacrimal gland. Ann Ophthalmol. 1975;1077–1078
  43. Ryder C, Naclerio RM. Multiple myeloma presenting as proptosis. Ann Otol Rhinol Laryngol. 1999;108:211–213
  44. Sen S, Kashyap S, Betharia SM. Primary plasmacytoma: a case report. Orbit. 2003;22(4):317–319
  45. Sharma A, Kaushal M, Chaturvedi NK, Yadav R. Cytodiagnosis of multiple myeloma presenting as orbital involvement: a case report. Cytojour. 2006;3:19
  46. Silkiss RZ, Pomerleau D, Sorenson A, et al. Corneal cupremia in multiple myeloma: a clinicopathologic correlation. Arch Ophthalmol. 2008;126(7):1005–1006
  47. Tetsumoto K, Iwaki H, Inoue M. IgG kappa extramedullary plasmacytoma of the conjunctiva and orbit. Br J Ophthalmol. 1993;77:255–257
  48. Thoumazet F, Donnio A, Ayeboua L, et al. Orbital and muscle involvement in multiple myeloma. Can J Ophthalmol. 2006;41(6):733–736
  49. Tuncbilek N, Karakas HM, Okten OO, et al. MRI in multiple myeloma with orbital and dural invasion. Tumori. 2005;91(3):270–272
  50. Valentine EA, Friedman HD, Zamkoff KW, et al. Necrobiotic xanthogranuloma with IgA multiple myeloma. Am J Hematol. 1990;35:383–385
  51. Yakulis R, Dawson RR, Wang SE, et al. Fine needle aspiration diagnosis of orbital plasmacytoma with amyloidosis: a case report. Acta Cytol. 1999;539(1):104–110
  52. Yeung SN, Paton KE, Dorovini-Zis K, et al. Histopathologic features of multiple myeloma involving the optic nerves. J Neuro Ophthalmol. 2008;28(1):12–16

 The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article. Supported in part by an unrestricted grant from Research to Prevent Blindness Inc., NY, NY.

PII: S0039-6257(09)00117-9

doi: 10.1016/j.survophthal.2009.04.012

Survey of Ophthalmology
Volume 54, Issue 6 , Pages 697-704 , November 2009