Survey of Ophthalmology
Volume 55, Issue 2 , Pages 169-173 , March 2010

Glazed (Vision) and Confused

  • Heather E. Moss, MD, PhD

      Affiliations

    • Division of Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • Corresponding Author InformationReprint address: Heather E. Moss, MD, PhD, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104.
    • ,
  • Grant T. Liu, MD

      Affiliations

    • Division of Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • ,
  • Josep Dalmau, MD, PhD

      Affiliations

    • Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

References 

  1. Antoine JC, Honnorat J, Camdessanche JP, et al. Paraneoplastic anti-CV2 antibodies react with peripheral nerve and are associated with a mixed axonal and demyelinating peripheral neuropathy. Ann Neurol. 2001;49:214–221
  2. Bataller L, Wade DF, Graus F, et al. Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. Neurology. 2004;62:778–782
  3. Cross SA, Slomao DR, Parisi JE, et al. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann Neurol. 2003;54:38–50
  4. Honnorat J, Antoine JC, Derrington E, et al. Antibodies to a subpopulation of glial cells and a 66 kDa developmental protein in patients with paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiat. 1996;61:270–278
  5. Honnorat J, Cartalat-Carel S, Ricard D, et al. Onco-neural antibodies and tumor type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies. J Neurol Neurosurg Psychiat. 2009;80:412–416
  6. Tuzun E, Dalmau J. Limbic encephalitis and variants: classification, diagnosis and treatment. Neurologist. 2007;13:261–271
  7. Vernino S, Tuite P, Adler CH, et al. Paraneoplastic Chorea associated with CRMP-5 Neuronal antibody and lung carcinoma. Ann Neurol. 2002;51:625–630
  8. Yu Z, Kryzer TJ, Griesmann GE, et al. CRMP–5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol. 2001;49:146–154

 The authors wish to thank Dr. Darma Ie for performing the retina evaluation, biopsying the vitreous, and providing the fundus photos. The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article.

PII: S0039-6257(09)00187-8

doi: 10.1016/j.survophthal.2009.03.008

Survey of Ophthalmology
Volume 55, Issue 2 , Pages 169-173 , March 2010

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