Survey of Ophthalmology
Volume 55, Issue 5 , Pages 460-466, September 2010

Multiple Sclerosis on Steroids

  • Matthew S. Johnson, MD

      Affiliations

    • Departments of Ophthalmology, Neurology, and Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Michael S. Lee, MD

      Affiliations

    • Departments of Ophthalmology, Neurology, and Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA
    • Corresponding Author InformationReprint address: Michael S. Lee, MD, 420 Delaware St SE, MMC 493, Minneapolis, MN 55455.
    • ,
  • Brian R. Younge, MD

      Affiliations

    • Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    • ,
  • Valerie Purvin, MD

      Affiliations

    • Indiana University Medical Center and Midwest Eye Institute, Indianapolis, Indiana, USA

published online 29 March 2010.

Peter Savino and Helen Danesh-Meyer, Editors

Abstract 

A 57-year-old man developed acute bilateral vision loss clinically consistent with bilateral optic neuritis. Within 1 month of diagnosis, he developed progressive and severe neurologic dysfunction, and repeat MRI demonstrated enhancement of the optic chiasm and optic tracts, as well as a large enhancing lesion within the right parieto-occipital lobe. Stereotactic-guided brain biopsy demonstrated demyelination consistent with multiple sclerosis. A diagnosis of fulminant multiple sclerosis was made. The patient died within 2 months of diagnosis. Multiple sclerosis and a fulminant subtype known as Marburg disease are discussed.

Key words: bilateral visual loss, fulminant, Marburg, multiple sclerosis, optic neuritis, treatment

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 The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article. Dr. Lee received an unrestricted grant from Research to Prevent Blindness, New York, NY, and the Lions Club of Minnesota.

PII: S0039-6257(09)00305-1

doi:10.1016/j.survophthal.2009.11.002

Survey of Ophthalmology
Volume 55, Issue 5 , Pages 460-466, September 2010

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