Survey of Ophthalmology
Volume 55, Issue 4 , Pages 386-392 , July 2010

Combined Optic Neuropathy and Myelopathy Secondary to Copper Deficiency

  • Stacy L. Pineles, MD

      Affiliations

    • Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • Corresponding Author InformationReprint address: Dr Steven L Galetta, 3400 Spruce Street, Philadelphia, PA 19104.
    • ,
  • Christina A. Wilson, MD, PhD

      Affiliations

    • Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • ,
  • Laura J. Balcer, MD, MSCE

      Affiliations

    • Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • Department of Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • ,
  • Robert Slater, MD

      Affiliations

    • Department of Neurology, Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, USA
    • ,
  • Steven L. Galetta, MD

      Affiliations

    • Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    • Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

References 

  1. Gregg XT, Reddy V, Prachal JT. Copper deficiency masquerading as myelodysplastic syndrome. Blood. 2002;100:1493–1495
  2. Juhasz-Pocsine K, Rudnicki SA, Archer RL, et al. Neurologic complications of gastric bypass surgery for morbid obesity. Neurology. 2007;68(21):1843–1850
  3. Konagaya M, Matsumoto A, Takase S, et al. Clinical analysis of long lasting subacute myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban. J Neurol Sci. 2004;218:85–90
  4. Kumar N, Gross JB, Ahlskog JE. Myelopathy due to copper deficiency. Neurology. 2003;61:273–274
  5. Kumar N, Gross JB, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology. 2004;63:33–39
  6. Kozak SF, Inderlied CB, Hsu HY, Heller KB, Sadun AA. The role of copper on Ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diagn Microbial Infect Dis. 1998;30:83–87
  7. Naismith RT, Shepherd JB, Weihl CC, et al. Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol. 2009;66(8):1025–1027
  8. Spinazzi M, De Lazzari F, Tavolato B, et al. Myelo-optico-neuropathy in copper deficiency occurring after partial gastrectomy: do small bowel bacterial overgrowth syndrome and occult zinc ingestion tip the balance?. J Neurol. 2007;254(8):1012–1017
  9. Tan JC, Burns DL, Jones RH. Severe ataxia, myelopathy, and peripheral neuropathy due to acquired copper deficiency in a patient with history of gastrectomy. JPEN J Parenter Enteral Nutr. 2006;30(5):446–450
  10. Van Campen DR, Mitchel EA. Absorption of Cu64, Zn65, Mo99, and Fe59 from ligated segments of the rat gastrointestinal tract. J Nutr. 1965;86:120–124

 The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article.

PII: S0039-6257(10)00040-8

doi: 10.1016/j.survophthal.2010.02.002

Survey of Ophthalmology
Volume 55, Issue 4 , Pages 386-392 , July 2010

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