Survey of Ophthalmology
Volume 55, Issue 6 , Pages 584-589 , November 2010

Orbital Lobular Panniculitis in Weber-Christian Disease: Sustained Response to Anti-TNF Treatment and Review of the Literature

  • Ioannis Mavrikakis, MD

      Affiliations

    • Department of Ophthalmology, Metropolitan Hospital, Athens, Greece
    • Corresponding Author InformationReprint address: Ioannis Mavrikakis, MD, PhD, Solonos 18, Kolonaki 106 73, Athens, Greece.
    • ,
  • Thomas Georgiadis, MD

      Affiliations

    • Department of Pathology, Metropolitan Hospital, Athens, Greece
    • ,
  • Kalliopi Fragiadaki, MD

      Affiliations

    • 1st Department of Propaedeutic Medicine, Laikon Hospital, Athens, Greece
    • ,
  • Petros P. Sfikakis, MD

      Affiliations

    • 1st Department of Propaedeutic Medicine, Laikon Hospital, Athens, Greece

References 

  1. Al-Niaimi F, Clark C, Thorrat A, et al. Idiopathic lobular panniculitis: remission induced and maintained with infliximab. Br J Dermatol. 2009;161(3):691–692
  2. Baskan EB, Saricaoglu H, Tunali S, et al. Effective treatment of relapsing idiopathic nodular panniculitis (Pfeifer-Weber-Christian disease) with mycophenolate mofetil. J Dermatolog Treat. 2003;14(1):57–60
  3. Beutler BA, Milsark IW, Cerami A. Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J Immunol. 1985;135(6):3972–3977
  4. Cook JN, Kikkawa DO. Proptosis as the manifesting sign of Weber-Christian disease. Am J Ophthalmol. 1997;124(1):125–126
  5. Hyun SH, Kang YM, Kim CD, et al. Weber-Christian disease presenting with proptosis: a case report. J Korean Med Sci. 2000;15(2):247–250
  6. Iwasaki T, Hamano T, Ogata A, et al. Successful treatment of a patient with febrile, lobular panniculitis (Weber-Christian disease) with oral cyclosporin A: implications for pathogenesis and therapy. Intern Med. 1999;38(7):612–614
  7. Kirch W, Duhrsen U, Hoensch H, et al. Cyclophosphamide-induced remission in Weber-Christian panniculitis. Rheumatol Int. 1985;5(5):239–240
  8. McNutt NS, Moreno A, Contreras F. Inflammatory disease of the subcutaneous fat. In:  Elder DE, et al. editor. Lever's Histopathology of the Skin. ed10. Philadelphia, PA: Lippincott; 1997;p. 523–524
  9. Panush RS, Yonker RA, Dlesk A, et al. Weber-Christian disease. Analysis of 15 cases and review of the literature. Medicine (Baltimore). 1985;64(3):181–191
  10. Theodossiadis PG, Markomichelakis NN, Sfikakis PP. Tumor necrosis factor antagonists: preliminary evidence for an emerging approach in the treatment of ocular inflammation. Retina. 2007;27(4):399–413
  11. Wang HP, Huang CC, Chen CH, et al. Weber-Christian disease presenting with intractable fever and periorbital swelling mimicking angioedema. Clin Rheumatol. 2007;26(6):1002–1004
  12. Yoshida T, Ito H, Matsubara Y, et al. Weber-Christian disease presenting with ocular manifestations. Clin Rheumatol. 2003;22(4-5):339–342

 The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article.

PII: S0039-6257(10)00087-1

doi: 10.1016/j.survophthal.2010.05.001

Survey of Ophthalmology
Volume 55, Issue 6 , Pages 584-589 , November 2010

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