Survey of Ophthalmology
Volume 42, Issue 4 , Pages 297-319 , January 1998

Keratoconus

  • Yaron S. Rabinowitz, MD

      Affiliations

    • Cornea-Genetic Eye Medical Clinic, Burns and Allen Research Institute, Cedars-Sinai Medical Center and the Department of Ophthalmology, UCLA School of Medicine, Los Angeles, California, USA

References 

  1. Abelson MB, Collin HB, Gillete TE, Dohlman CH. Recurrent keratoconus after keratoplasty. Am J Ophthalmol. 1980;90:672–676
  2. Alstrom CH, Olson O. Heredo-retinopathia congenitalis. Monohybride recessiva autosomalis. Hereditas Genttiskt. 1957;43:1–177
  3. Amsler M. Le keratocone fruste au javal. Ophthalmologica. 1938;96:77–83
  4. Amsler M. Keratocone classique et keratocone fruste, arguments unitaires. Ophthalmologica. 1946;111:96–101
  5. Archer DB, Sharma NK. Irido-corneal dysgenesis. Trans Ophthalmol Soc UK. 1978;98:510
  6. Austin MG, Schaefer RF. Marfan’s syndrome with unusual blood vessel manifestations. Arch Pathol. 1957;64:204–209
  7. Beardsley TL, Foulks GN. An association of keratoconus and mitral valve prolapse. Ophthalmology. 1982;89:35–37
  8. Beckh U, Schonherr U, Naumann GO. Augenklinik mit Poliklinik, Universitat Erlangen-Nurnberg. Autosomal dominant keratoconus as the chief ocular symptom in Lobstein osteogesis imperfecta tarda. Klin Monatsbl Augenheilkd. 1995;206:268–272
  9. Bereau J, Fabre EJ, Hecquet C, et al.  Modification of prostaglandin E2 and collagen synthesis in keratoconus fibroblasts associated with an increase of interleukin-1 alpha receptor number. CR Acad Sci, Paris. 1993;316(III):425–430
  10. Bisaria KK. Bilateral keratoconus with ocular hypertension and the natural cure of one eye. J All India Ophthalmol Soc. 1967;15:197–199
  11. Blair SD, Seabrooks D, Shields JW, et al.  Bilateral progressive essential iris atrophy and keratoconus with coincident features of posterior polymorphous dystrophy (a case report and proposed pathogenesis). Cornea. 1992;11:255–261
  12. Blanksma LJ, Donders PC, Van Voorst Vander PC. Xeroderma Pigmentosum and keratoconus. Doc Ophthalmol. 1986;64:97–103
  13. Brenner S, Nemet P, Legum C. Jadasohn-type anetoderma in association with keratoconus and cataract. Ophthalmologica. 1977;174:181–184
  14. Bron A, Rabinowitz YS. Corneal dystrophies and keratoconus. Curr Opin Ophthalmol. 1996;7:71–82
  15. Brown IA. Ankyloblepharon associated with keratoconus. Br J Ophthalmol. 1967;51:138–139
  16. Buiuc S, Beschea G, Jaobleceastai L, Dimitriu G. A case of bilateral posterior lenticonus associated with keratoconus. Rev Chir Oftalmol. 1978;22:299–300
  17. Buxton JN. Contact lenses in keratoconus. Contact Intraocular Lens Med J. 1978;4:74
  18. Buxton JN, Keates RH, Hoefle FB. The contact lens correction of keratoconus. In:  Diabezes OH editors. Contact Lenses. The CLAO Guide to Basic Science and Clinical Practice. Orlando: Grune and Stratton; 1984;
  19. Buzard KA, Fundingsland BR. Cornea transplants for keratoconus. Results in early and late disease. J Refract Surg. 1997;23:398–496
  20. Byers PH. Disorders of collagen biosynthesis and structure. In:  Scriver CR,  Beaudet AL,  Sly WS,  Valle D editor. Metabolic Basis of Inherited Disease. 7. New York: McGraw Hill; 1995;p. 4029–4077
  21. Cantor RM, Rotter JI: Analysis of genetic data: methods and interpretation, in King RA, Rotter JI, Motulsky AG (eds): The Genetic Basis of Common Diseases. 1992, pp 49–70
  22. Cavara V. Keratoglobus and keratoconus. Br J Ophthalmol. 1950;34:621
  23. Conneally PM, Rivas ML. Linkage analysis in man. Adv Hum Genet. 1980;10:209–266
  24. Cullen JF, Butler HG. Mongolism (Down’s Syndrome) and keratoconus. Br J Ophthalmol. 1963;47:321–330
  25. Donaldson DD. A new instrument for keratography. Arch Ophthalmol. 1972;88:425–428
  26. Driver PJ, Reed JW, David RM. Familial cases of keratoconus associated with posterior polymorphous dystrophy (letter). Am J Ophthalmol. 1994;118:256–257
  27. Duke-Elder S, Leigh AG. System of ophthalmology. Diseases of the outer eye, Vol 8. London: Henry Kimpton; 1965;pp 964–976
  28. Durand L, Monot JP, Burillon C, Assi A. Radial keratotomy in a patient with keratoconus. Refract Corneal Surg. 1991;7:374–376
  29. Eiferman RA, Law MW, Lane L. Iridoschisis and keratoconus. Cornea. 1994;13:78–79
  30. Elder MJ. Leber congenital amaurosis and its association with keratoconus and keratoglobus. J Pediatr Ophthalmol Strabismus. 1994;31:38–40
  31. Elston RC. Segregation analysis. Adv Hum Genet. 1981;11:63–120
  32. Enoch E, Itzahki A, Lakshminarayanan V, et al.  Visual field defects detected in patients with Gilles de la Tourette syndrome (preliminary report). Int Ophthalmol. 1989;13:331–344
  33. Etzine S. Conical cornea in identical twins. S Afr Med J. 1954;28:154–155
  34. Falls HF, Allen W. Dominantly inherited keratoconus. Report of a family. J Genet Hum. 1969;17:317
  35. Franceschetti A: Keratoconus, in King JH, McTigue JW (eds): The Cornea. World Congress. Washington, Butterworths, 1965, pp 152–168
  36. Francois J: Afflictions of the cornea, in Francois J (ed): Heredity in Ophthalmology. St Louis, CV Mosby, 297–298, 1961
  37. Francois J, Neetens A, Smets RM. Bardet-Biedl syndrome and keratoconus. Bull Soc Ophthalmol. 1982;203:117–121
  38. Frasca G, Belmonte M: Neurocutaneous angiomatosis and keratoconus. A new syndrome entity? Riv Otoneurooftalmol 41:119–130, 1966
  39. Freedman J, Gombos GM. Bilateral macular coloboma, keratoconus and retinitis pigmentosa. Ann Ophthalmol. 1971;3:664–665
  40. Filip O, Golu T, Filip I, et al.  Keratoconus in Albers-Schonberg disease. Oftalmologia. 1994;38:247–251
  41. Fukuchi T, Yue B, Sugar J, Lam S. Lysosomal enzyme activities in conjunctival tissues of patients with keratoconus. Arch Ophthalmol. 1994;112:1368–1374
  42. Gasset AR, Houde WI, Garcia-Bengochea H. Contact lens wear as an environmental risk in keratoconus. Am J Ophthalmol. 1978;85:339–341
  43. Gasset AR, Worthen DM. Keratoconus and Chandler’s syndrome. Ann Ophthalmol. 1974;6:819–820
  44. Geerarts WJ. Ocular Syndromes. Philadelphia: Lea and Febiger; 1969;ed 2
  45. Girard LJ, Esnaola N, Rao R, et al.  Use of grafts smaller than the opening for keratoconic myopia and astigmatism. J Cataract Refract Surg. 1992;18:380–384
  46. Gonzalez V, McDonnell PJ. Computer-assisted corneal topography of parents in patients with keratoconus. Arch Ophthalmol. 1992;110:1413–1414
  47. Gormley DJ, Gersten M, Koplin RS, Lubkin V. Corneal modeling. Cornea. 1988;7:30
  48. Grayson M, Keates RH. Manual of diseases of the cornea. Boston: Little Brown; 1969;ed 1
  49. Greenfield G, Romano A, Stein R, Goodman RM. Blue sclerae and keratoconus. Key features of a distinct heritable disorder of connective tissue. Clin Genet. 1973;4:8–16
  50. Hallerman W, Wilson EJ. Genetische betrachtungen uber den keratoconus. Klin Monatsbl Augenheilkd. 1977;170:906–908
  51. Hammerstien W. Zur genetik des keratoconus. Graefes Arch Klin Exp Ophthalmol. 1974;190:293–308
  52. Hannush SB, Crawford SL, Waring GO, et al.  Accuracy and precision of keratometry, photokeratoscopy, and corneal modeling on calibrated steel balls. Arch Ophthalmol. 1989;107:1235–1239
  53. Hartstien J. Keratoconus that developed in patients wearing corneal contact lenses. Arch Ophthalmol. 1968;80:345–346
  54. Hoang-Xuan T, Elmaleh C, Dhermy P, et al.  Association of a lattice dystrophy and keratoconus (anatomo-clinical study apropos of a case). Bull Soc Ophthalmol Fr. 1989;89:35–38
  55. Hofstetter H. A keratoscopic survey of 13,395 eyes. Am J Optom Acad Optom. 1959;36:3–11
  56. Ihalainen A. Clinical and epidemiological features of keratoconus (genetic and external factors in the pathogenesis of the disease). Acta Ophthalmol. 1986;178(Suppl):5–64
  57. Iwaszkiewicz E. Keratoconus. II. Coexisting diseases and theories on its etiology and pathogenesis. Klin Oczna. 1989;91:210–211
  58. Judisch GF, Waziri M, Krachmer J. Ocular Ehlers-Danlos syndrome with normal lysyl hydroxylase activity. Arch Ophthalmol. 1976;94:1489
  59. Kayazawa F, Nishimura K, Kodama Y, et al.  Keratoconus with pellucid marginal corneal degeneration. Arch Ophthalmol. 1984;102:895–896
  60. Kennedy RH, Bourne WM, Dyer JA. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol. 1986;101:267–273
  61. Kenney MC, Chwa M, Opbroek AJ, et al.  Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metaloproteinase ratio. Cornea. 1994;13:108–113
  62. Kirkham TH, Werner EB. The ophthalmic manifestations of Rothmund’s syndrome. Can J Ophthalmol. 1975;10:1–14
  63. Klintworth GK. Degenerations, depositions and miscellaneous reactions of the ocular anterior segment. In:  Garner A,  Klintworth GK editor. Pathobiology of Ocular Disease (A Dynamic Approach). 2. New York: Marcel Dekker; 1994;p. 743–794
  64. Klintworth GK, Damms T. Corneal dystrophies and keratoconus. Curr Opin Ophthalmol. 1995;6:44–56
  65. Klyce SD. Computer-assisted corneal topography. High resolution graphic presentation and analysis of keratoscopy. Invest Ophthalmol Vis Sci. 1984;25:1426–1435
  66. Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293–322
  67. Kremer I, Eagle RC, Rapuano CJ, Laibson PR. Histologic evidence of recurrent keratoconus seven years after keratoplasty. Am J Ophthalmol. 1995;119:511–512
  68. Kremer I, Martini AM, Cohen EJ. Keratoconus associated with ectodermal and mesodermal anomalies (letter). CLAO J. 1992;18:141
  69. Kumig BS, Joffe L. Ehlers-Danlos syndrome associated with keratoconus. S Afr Med J. 1977;52:403–405
  70. Lass JH, Stocker EG, Fritz ME, Collie DM. Epikeratoplasty. The surgical correction of aphakia, myopia, and keratoconus. Ophthalmology. 1987;94:912–925
  71. Lee LR, Hirst LW, Readshaw G. Clinical detection of unilateral keratoconus. Aust N Z J Ophthalmol. 1995;23:129–133
  72. Levene JR. An evaluation of the handheld keratoscope as a diagnostic instrument for corneal astigmatism. Br J Physiol Opt. 1962;19:237–251
  73. Lipman RM, Rubenstein JB, Torczynski E. Keratoconus and Fuchs’ corneal endothelial dystrophy in a patient and her family. Arch Ophthalmol. 1990;108:993–994
  74. Lorfel RS, Sugar HS. Keratoconus associated with retrolental fibroplasia. Ann Ophthalmol. 1976;8:449–450
  75. Lund AM: The Angelman syndrome. Does the phenotype depend on maternal inheritance? Ugeskr Laeger 153:1993–1998, 1991
  76. Maeda N, Klyce SD, Smolek MK, Thompson HW. Automated keratoconus screening with corneal topography analysis. Invest Ophthalmol Vis Sci. 1994;35:2749–2757
  77. Maeda N, Klyce SD, Smolek MK. Comparison of methods for detecting keratoconus using videokeratography. Arch Ophthalmol. 1995;113:870–874
  78. Maguire LJ, Bourne W. Corneal topography of early keratoconus. Am J Opthalmol. 1989;108:107–112
  79. Maguire LJ, Klyce SD, McDonald ME, Kaufmann HE. Corneal topography of pellucid marginal degeneration. Ophthalmology. 1987;94:519–524
  80. Maguire LJ, Meyer RF: Ectatic corneal degenerations, in Kaufman H (ed): The Cornea. 1988, pp 485–510
  81. Maguire LJ, Wilson SE, Camp JJ, Verity S. Evaluating the reproducibility of topography systems on spherical surfaces. Arch Ophthalmol. 1993;111:259–262
  82. Mammilis N, Montgomery S, Anderson C, et al.  Radial keratotomy in a patient with keratoconus. Refract Corneal Surg. 1991;7:374–376
  83. McKusick VA: Heritable Diseases of Connective Tissue. St Louis, CV Mosby, 1966, ed 3
  84. McKusick VA. Inherited disorders of connective tissue. In:  Harrison TR editors. Principles of Internal Medicine. 7. New York: McGraw Hill; 1974;p. 2015–2020
  85. Merlin U, Cantera E: Corneal topography, in Burrato L (ed): The Clinical Atlas thoroughfare, New Jersey, Slack, 1996, pp 9–93
  86. Mortensen J, Ohrstrom A. Excimer laser photorefractive keratectomy for treatment of keratoconus. J Refract Corneal Surg. 1994;10:368–372
  87. Morton NE: Segregation analysis, in Computer Applications in Genetics, Honolulu, University of Hawaii Press, 1969, pp 129–139
  88. Negris R. Floppy eyelid syndrome associated with keratoconus. J Am Optom Assoc. 1992;63:316–319
  89. Nesburn AB, Bahri S, Salz J, et al.  Keratoconus detected by videokeratography in candidates for photorefractive keratectomy. J Refract Surg. 1995;11:194–201
  90. Nirankari VS, Karesh J, Bastion F, et al.  Recurrence of keratoconus in a donor cornea 22 years after successful keratoplasty. Br J Ophthalmol. 1983;67:32
  91. Nucci P, Brancato R. Keratoconus and congenital hip dysplasia (letter). Am J Ophthalmol. 1991;111:775–776
  92. Nucci P, Trabucchi G, Brancato R. Keratoconus and Turner’s syndrome (a case report). Optom Vis Sci. 1991;68:407–408
  93. Opbroek A, Kenney MC, Brown D. Characterization of a human corneal metalloproteinase inhibitor (TIMP-1). Curr Eye Res. 1993;12:877–883
  94. Parker J, Ko W, Pavlopoulos G, et al.  Videokeratography of keratoconus in monozygotic twins. J Refract Surg. 1996;12:180–183
  95. Peduzzi MD, Torlai F, Delvecchio G. Bilateral pigmented retinopathy following measles (long term follow up and possible association with keratoconus). Eur J Ophthalmol. 1991;1:148–150
  96. Perlman JM, Zaidman GW. Bilateral keratoconus in Crouzon’s syndrome. Cornea. 1994;13:80–81
  97. Perry HD, Buxton JN, Fine BS. Round and oval cones in keratoconus. Ophthalmology. 1980;87:905–909
  98. Price FW, Whitson WE, Marks RG. Graft survival in four common groups of patients undergoing penetrating keratoplasty. Ophthalmology. 1991;98:322–328
  99. Rabinowitz YS. Tangential vs sagittal videokeratographs in the “early” detection of keratoconus. Am J Ophthalmol. 1996;122:888–889
  100. Rabinowitz YS. Videokeratographic indices to aid in screening for keratoconus. J Refract Surg. 1995;11:371–379
  101. Rabinowitz YS, Garbus JJ, Garbus C, McDonnell PJ. Contact lens selection for keratoconus using a computer-assisted videophotokeratoscope. CLAO J. 1991;17:88–93
  102. Rabinowitz YS, Garbus J, McDonnell PJ. Computer-assisted corneal topography in family members of keratoconus. Arch Ophthalmol. 1990;108:365–371
  103. Rabinowitz YS, Klyce SD, Krachmer JH, et al.  Videokeratography, keratoconus, and refractive surgery. Opinions. Refract Corneal Surg. 1992;5:403–407
  104. Rabinowitz YS, McDonnell PJ. Computer-assisted corneal topography in keratoconus. Refract Corneal Surg. 1989;5:400–406
  105. Rabinowitz YS, Maumenee IH, Lundergan MK, et al.  Molecular genetic analysis in autosomal dominant keratoconus. Cornea. 1992;11:302–308
  106. Rabinowitz YS, Nesburn AB, McDonnell PJ. Videokeratography of the fellow eye in unilateral keratoconus. Ophthalmology. 1993;100:181–186
  107. Rabinowitz YS, Riley C, Yang H, et al.  Videokeratography studies of keratoconus parents (abstract). Invest Ophthalmol Vis Sci. 1995;36(Suppl):S308
  108. In:  Rabinowitz YS,  Wilson SE,  Klyce SD editor. Corneal Topography (Interpreting Videokeratography). New York: Tokyo; 1993;Igaku Shoin
  109. Rabinowitz YS, Yang H, Akkina J, et al.  Videokeratography of normal human corneas. Br J Ophthalmol. 1996;80:610–616
  110. Rabinowitz YS, Yang H, Elashoff J, Rotter J. The KI-SA% index (a quantitative new videokeratography algorithm embodying minimal topographic criteria for diagnosing keratoconus and “suspects” (abstract)). Invest Ophthalmol Vis Sci. 1996;37(Suppl):S910
  111. Rabinowitz YS, Yang H, Elashoff J, Rotter J: Familiality in keratoconus and related topographic measures. Proceedings of the World Congress of the Cornea IV (Abstract). Abstract Book. VIII Keratoconus, 1996, p 2
  112. Rabinowitz YS, Yang H, Elashoff J, Rotter J. Videokeratography indicators of “early” keratoconus (abstract). Invest Ophthalmol Vis Sci. 1993;34(Suppl):S1218
  113. Rabinowitz YS, Yang H, Elashoff J, Rotter J: Videokeratography and pachymetry studies in keratoconus (abstract). Ophthalmology (Suppl):67, 1993
  114. Rahi A, Davies P, Ruben M, et al.  Keratoconus and coexisting atopic disease. Br J Ophthalmol. 1977;61:761
  115. Rau S, Duncker GI. Keratoconus in Mulvihill-Smith syndrome. Klin Monatsbl Augenheilkd. 1994;205:44–46
  116. Redmond KB. The role of heredity in keratoconus. Trans Ophthalmol Soc. 1968;27:52–54
  117. Ricci B, Lepore D, Iossa M, et al.  Ocular anomalies in Alagille’s syndrome (Anomalies oculaires dans le syndrome d’Alagille). J Fr Ophthalmol. 1991;14:481–485
  118. Robertson I. Keratoconus and Ehlers Danlos syndrome. A new aspect of keratoconus. Med J Aust. 1975;1:571–573
  119. Rose NJ, Mackay K, Byers PH, Dalgleish R. A Gly238Ser substitution in the alpha 2 chain of type I collagen results in osteogenesis imperfecta type III. Hum Genet. 1995;95:215–218
  120. Rosenthal P, Cotter JM. Clinical performance of a spline-based apical vaulting keratoconus corneal contact lens design. CLAO J. 1995;21:42–46
  121. Rowsey JJ, Reynolds AE, Brown R. Corneal topography. Corneascope. Arch Ophthalmol. 1981;99:1093–1100
  122. Sassani JW, Smith SG, Rabinowitz YS. Keratoconus and bilateral lattice-granular corneal dystrophies. Cornea. 1992;11:343–350
  123. Sawagamuchi S, Twinning SS, Yue BY, et al.  Alpha 2 macroglobulin levels in normal human and keratoconus corneas. Invest Ophthalmol Vis Sci. 1994;35:4008–4014
  124. Sawagamuchi S, Yue BYT, Sugar J, Giljoy JE. Lysosomal abnormalities in keratoconus. Arch Ophthalmol. 1989;107:1507–1510
  125. Schanzlin DJ, Samo EM, Robin JB. Crescentic lamellar keratoplasty in pellucid marginal degeneration. Am J Ophthalmol. 1983;96:253
  126. Schwartz DE. Noonan’s syndrome associated with ocular abnormalities. Am J Ophthalmol. 1972;73:955–960
  127. Sczhotka L, Rabinowitz YS, Yang H. The influence of contact lens wear on the topography of keratoconus. CLAO J. 1996;22:270–273
  128. Shammas HJ, McGaughey AS. Retinal disinsertion syndrome (report of a case). J Pediatr Ophthalmol Strabismus. 1979;16:284–286
  129. Shapiro MB, France T. The ocular features of Down’s syndrome. Am J Ophthalmol. 1985;99:659
  130. Sharif KW, Casey TA, Colart J. Prevalence of mitral valve prolapse in keratoconus patients. J R Soc Med. 1992;85:446–448
  131. Sharif KW, Casey TA. Penetrating keratoplasty for keratoconus (complications and long term success). Br J Ophthalmol. 1991;75:142–146
  132. Shows TB, Sakaguchi AY, Naylor SL. Mapping the human genome, cloned genes, DNA polymorphisms, and inherited disease. Adv Hum Genet. 1982;12:341–468
  133. Smiddy WE, Hamburg TR, Kracher GP, Stark WJ: Keratoconus. Contact lens or keratoplasty? Ophthalmology 95:487–492, 1988
  134. Smith VA, Hoh VB, Littleton L, Easty DL. Overexpression of gelatinase A activity in keratoconus. Eye. 1995;9:429–433
  135. Smolin G. Dystrophies and degenerations. In:  Smolin G,  Thoft RA editor. The Cornea (Scientific Foundations and Clinical Practice). 2. Boston: Little, Brown; 1987;p. 448–449
  136. Stokes DW, Parrish CM. Axenfeld’s anomaly associated with Down’s syndrome. Cornea. 1992;11:163–164
  137. Stone DL, Kenyon KR, Stark WJ. Ultrastructure of keratoconus with healed hydrops. Am J Ophthalmol. 1976;82:450–458
  138. Street DA, Vinokur ET, Waring GO, et al.  Lack of association between keratoconus, mitral valve prolapse and joint hypermobility. Ophthalmology. 1991;98:170–176
  139. Thalasselis A, Selim AA. Keratoconus-tetany-menopause (the new association). Optom Vis Sci. 1991;68:357–363
  140. Thompson JS, Thompson MW. Twins in medical genetics in genetics in medicine. Philadelphia, WB: Saunders; 1986;
  141. Tiller G, Cohn D, Rabinowitz YS. Linkage analysis in familial keratoconus (abstract). Invest Ophthalmol Vis Sci. 1992;33(Suppl):S793
  142. Tretter T, Rabinowitz YS, Yang H, et al.  Aetiological factors in keratoconus. Ophthalmology. 1995;102(Suppl):156
  143. Tuft SJ, Buckley RJ. Iris ischaemia following penetrating keratoplasty for keratoconus (Urets-Zavalia syndrome). Cornea. 1995;14:618–622
  144. Tuft SJ, Fitzke FW, Buckley RJ. Myopia following penetrating keratoplasty for keratoconus. Br J Ophthalmol. 1992;76:642–645
  145. Tuft SJ, Gregory WM, Davidson CR. Bilateral penetrating keratoplasty for keratoconus. Ophthalmology. 1995;102:462–468
  146. Tuft SJ, Moodaley LC, Gregory WM, et al.  Prognostic factors of progression to keratoconus. Ophthalmology. 1994;101:439–447
  147. Verrey F. Keratoglobe aigu. Ophthalmologica. 1947;114:284
  148. Wachmeister L, Ingemannsson SO, Moller E. Atopy and HLA antigens in patients with keratoconus. Acta Ophthalmol (Copenh). 1982;60:113
  149. Waller SG, Steinert RF, Wagoner MD. Long-term results of epikeratoplasty for keratoconus. Cornea. 1995;14:84–88
  150. Walsh FB, Hoyt WF. Clinical neuro-ophthalmology. Baltimore: Williams and Wilkins; 1969;ed 3
  151. Ward MA, Artunduaga G, Thompson KP, et al.  Phototherapeutic keratectomy for the treatment of nodular subepithelial corneal scars in patients with keratoconus who are contact lens intolerant. CLAO J. 1995;21:130–132
  152. Waring GO, Rabinowitz YS, Sugar J, et al.  Nomenclature for keratoconus suspects. Refract Corneal Surg. 1993;9:219–221
  153. Williams KA, Muehlberg SM, Lewis RF, Coster DJ. How successful is corneal transplantation? A report from the Australian Corneal Graft Register. Eye. 1995;9:219–227
  154. Wilson SE, He YG, Weng J, et al.  Epithelial injury induces keratocyte apoptosis (Hypothesized role for the interleukin 1 system in the modulation of corneal tissue organization and wound healing). Exp Eye Res. 1996;62:325–337
  155. Wilson SE, Klyce SD. Screening for corneal topographic abnormalities before refractive surgery. Ophthalmology. 1994;101:147–152
  156. Wilson SE, Klyce SD, Husseini MD. Standardized color coded maps for corneal topography. Ophthalmology. 1993;100:1723–1727
  157. Wilson SE, Lin DTC, Klyce SD. The topography of keratoconus. Cornea. 1991;10:2–8
  158. Wilson SE, Lin DTC, Klyce SD, et al.  Topographic changes in contact lens-induced corneal warpage. Ophthalmology. 1990;97:734–744
  159. Wilson SE, Lin DTC, Klyce SD, Insler MS. The corneal topography of Terrien’s marginal degeneration. Refract Corneal Surg. 1990;6:15–20
  160. Wilson SE, Verity SM, Conger DL. Accuracy and reproducibility of the corneal analysis system and topographic modeling system. Cornea. 1992;11:28–35
  161. Wolter JR. Bilateral keratoconus in Crouzon’s syndrome with unilateral acute hydrops. J Pediatr Ophthalmol. 1977;14:141–143
  162. Yeung K, Egbahli F, Weissman BA. Clinical experience with piggyback contact lens systems on keratoconic eyes. J Am Optom Assoc. 1995;66:539–543
  163. Zala L, Ettlin C, Krebs A. Fokale dermal Hypoplasie mit Keratokonus. Osophaguspappillomen und Hidrokystomen. Dermatologica. 1975;150:176–185
  164. Zimmerman DL, Fischer RW, Winterhalter KH, et al.  Comparitive studies of collagens in normal and keratoconus corneas. Exp Eye Res. 1988;46:431–442
  165. Zolog N. On congenital blindness (Kurz syndroms) (Observations sur la cecite congenitale [Syndrome de Kurz]). Bull Mem Soc Fr Ophthalmol. 1969;82:113–116

PII: S0039-6257(97)00119-7

doi: 10.1016/S0039-6257(97)00119-7

Survey of Ophthalmology
Volume 42, Issue 4 , Pages 297-319 , January 1998